Do venlafaxine XR and paroxetine equally influence negative and positive affect?
Do venlafaxine XR and paroxetine equally influence negative and positive affect?
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DOI：
10.1016/j.jad.2004.10.007
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发表时间：
2005-04
影响因子：
6.6
通讯作者：
G. Dichter;A. Tomarken;C. Freid;S. Addington;R. Shelton
中科院分区：
文献类型：
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作者：
G. Dichter;A. Tomarken;C. Freid;S. Addington;R. Shelton
研究目的：评价文拉法辛缓释剂和帕罗西汀对情绪和焦虑症状的治疗作用。我们假设这两种抗抑郁药对负面情绪的症状有很大程度上相似的影响，因为这两种药物都影响多巴胺能系统。然而，基于证据表明，儿茶酚胺能活性和积极的情感层面之间的联系，我们假设，文拉法辛XR的儿茶酚胺能效应将产生特别明显的影响，对症状的积极affect.METHODSTwenty抑郁症门诊患者随机分配到治疗与文拉法辛XR（225毫克/天）或帕罗西汀（30毫克/天）在12周的治疗试验。使用情绪和焦虑症状问卷[沃森，D.，洛杉矶克拉克Weber，K.，Assenheimer，J.S.，施特劳斯，法医麦考密克，R.A.，1995.测试三方模型：II。探索学生，成人和患者样本中焦虑和抑郁的症状结构。J. Abnorm. [沃森，D.，Weber，K.，Assenheimer，J.S.，洛杉矶克拉克施特劳斯，法医麦考密克，R.A.，1995.测试三方模型：I。焦虑和抑郁症状量表的聚合效度和区分效度评价。J. Abnorm. Psychol. 104（1），3-14]。结果与预测一致，分析显示文拉法辛XR和帕罗西汀在负面情绪测量方面没有显着差异。然而，与预测相反，这两种药物产生了类似的变化措施的积极affect.LIMITATIONSReplication和扩展使用更大的样本量是mandatory. CONCLUSION这些初步结果表明，两种抗抑郁药，似乎有不同的作用机制，但可能有类似的影响，积极和消极的情感成分抑郁症。或者，帕罗西汀在试验剂量下可能具有临床相关的去甲肾上腺素能作用。
BACKGROUNDWe assessed the therapeutic effects of venlafaxine XR and paroxetine on mood and anxiety symptoms derived from the tripartite model of mood. We hypothesized that the two antidepressants would have largely similar effects on symptoms of negative affect because both agents influence serotonergic systems. However, based on evidence indicating linkages between catecholaminergic activity and the emotional dimension of positive affect, we hypothesized that the catecholaminergic effects of venlafaxine XR would yield particularly pronounced effects on symptoms of positive affect.METHODSTwenty depressed outpatients were randomly assigned to treatment with either venlafaxine XR (225 mg/day) or paroxetine (30 mg/day) during a 12-week treatment trial. Weekly mood ratings were collected using the Mood and Anxiety Symptom Questionnaire [Watson, D., Clark, L.A., Weber, K., Assenheimer, J.S., Strauss, M.E., McCormick, R.A., 1995. Testing a tripartite model: II. Exploring the symptom structure of anxiety and depression in student, adult, and patient samples. J. Abnorm. Psychol. 104 (1), 15–25] [Watson, D., Weber, K., Assenheimer, J.S., Clark, L.A., Strauss, M.E., McCormick, R.A., 1995. Testing a tripartite model: I. Evaluating the convergent and discriminant validity of anxiety and depression symptom scales. J. Abnorm. Psychol. 104 (1), 3–14].RESULTSConsistent with predictions, analyses revealed that there were no significant differences between venlafaxine XR and paroxetine on measures of negative affect. However, contrary to predictions, the two medications produced similar changes on measures of positive affect.LIMITATIONSReplication and extension using a larger sample size are mandated.CONCLUSIONSThese preliminary results suggest that two antidepressants that appear to have dissimilar mechanisms of action may nevertheless have similar effects on the positive and negative affective components of depression. Alternatively, paroxetine may have a clinically relevant noradrenergic effect at the dose tested.