Nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (T4) breast cancer.
Nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (T4) breast cancer.
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DOI：
10.4081/ejh.2011.e39
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发表时间：
2011-11-14
期刊：
影响因子：
--
通讯作者：
Sirigu P
中科院分区：
文献类型：
--
作者：
Piras F;Ionta MT;Lai S;Perra MT;Atzori F;Minerba L;Pusceddu V;Maxia C;Murtas D;Demurtas P;Massidda B;Sirigu P
巢蛋白是一种中间丝蛋白，传统上被认为是神经干细胞的重要标志物。然而，近年来，巢蛋白的表达已被证明与肿瘤内祖细胞群的一般增殖有关。目前还没有关于巢蛋白在T4乳腺癌患者中表达的研究报道。因此，本研究的目的是调查，通过免疫组织化学，巢蛋白在T4乳腺癌的表达和分布，以确定其与临床和病理参数以及患者的结果。巢蛋白在肿瘤细胞和血管内皮细胞中可检测到，并且在T4乳腺肿瘤的三阴性和炎性乳腺癌（IBC）亚组中显著表达。Kaplan-Meier分析显示，肿瘤细胞中巢蛋白的存在显著预测T4乳腺癌患者5年生存期的不良预后（P=0.02），10年生存期的边缘显著性（P=0.05）。基于这些观察结果，我们推测巢蛋白表达可能是肿瘤具有侵袭性临床行为的特征，这表明巢蛋白在肿瘤细胞和血管中的存在可能被认为是导致预后不良的重要因素。有待进一步的研究来确定巢蛋白在这些乳腺癌亚组病因学中的生物学作用。
Nestin, an intermediate filament protein, has traditionally been noted for its importance as a neural stem cell marker. However, in recent years, expression of nestin has shown to be associated with general proliferation of progenitor cell populations within neoplasms. There is no reported study addressing nestin expression in T4 breast cancer patients. Thus, the aim of the present study was to investigate, through immunohistochemistry, the expression and distribution of nestin in T4 breast cancer, in order to determine its association with clinical and pathological parameters as well as with patients' outcome. Nestin was detectable in tumoral cells and in endothelial cells of blood microvessels, and it is significantly expressed in triple-negative and in inflammatory breast cancer (IBC) subgroups of T4 breast tumours. The Kaplan-Meier analysis showed that the presence of nestin in tumoral cells significantly predicted poor prognosis at 5-years survival (P=0.02) and with borderline significance at 10-years of survival (P=0.05) in T4 breast cancer patients. On the basis of these observations, we speculate that nestin expression may characterize tumours with an aggressive clinical behavior, suggesting that the presence of nestin in tumoral cells and vessels may be considered an important factor that leads to a poor prognosis. Further studies are awaited to define the biological role of nestin in the etiology of these subgroups of breast cancers.
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影响因子：
6.2
作者：
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通讯作者：
Palmieri G