Fear extinction as a model for translational neuroscience: ten years of progress.
Fear extinction as a model for translational neuroscience: ten years of progress.
复制标题
恐惧灭绝作为转化神经科学的模型：十年的进步。
DOI：
10.1146/annurev.psych.121208.131631
复制
发表时间：
2012
影响因子：
24.8
通讯作者：
Quirk GJ
中科院分区：
文献类型：
--
作者：
Milad MR;Quirk GJ
灭绝的心理学已经研究了几十年。然而，大约10年前，人们开始共同努力了解动物和人类恐惧条件反射消失的神经回路。这一时期的进展得益于啮齿类动物和人类研究人员在研究恐惧消退方面不同寻常的协调。这个成功的研究项目可以作为行为神经科学其他领域转化研究的典范。在这里，我们回顾了主要进展，并强调了理解和利用恐惧消退的新方法。
The psychology of extinction has been studied for decades. Approximately 10 years ago, however, there began a concerted effort to understand the neural circuits of extinction of fear conditioning, in both animals and humans. Progress during this period has been facilitated by an unusual degree of coordination between rodent and human researchers examining fear extinction. This successful research program could serve as a model for translational research in other areas of behavioral neuroscience. Here we review the major advances and highlight new approaches to understanding and exploiting fear extinction.