[Clinical and pharmacokinetic studies on intravenous administration of sulbactam/ampicillin in pediatrics].
[Clinical and pharmacokinetic studies on intravenous administration of sulbactam/ampicillin in pediatrics].
复制标题
舒巴坦/氨苄西林在儿科静脉给药的临床及药代动力学研究
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
K. Niino
中科院分区：
文献类型：
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作者：
H. Sato;A. Narita;H. Suzuki;S. Nakazawa;K. Matsumoto;Y. Nakanishi;K. Niino
评价舒巴坦/氨苄西林(SBT/ABPC)静脉给药在儿科患者中的应用。静脉注射或静脉滴注20-35 mg/kg后，ABPC和SBT的血清半衰期均约为1小时，尿中ABPC和SBT的半衰期分别为30-50%和30-70%。静脉滴注58 mg/kg后1h，脑脊液中ABPC和SBT浓度分别为0.76和0.68微克/毫升，脑脊液/血清浓度比分别为6.39和5.71%。应用SBT/ABPC 54~150 mg/kg，分3次静脉滴注治疗34例患儿。临床有效率93.5%，细菌清除率92.3%。在本研究中，舒巴坦和氨苄西林对患者分离的产β-内酰胺酶金黄色葡萄球菌和流感嗜血杆菌有协同作用。34例患者中有6例观察到SBT/ABPC的副作用，其中腹泻5例，腹泻伴呕吐1例。嗜酸性粒细胞增多(2例)，谷草转氨酶(GOT)、谷丙转氨酶(GPT)、乳酸脱氢酶(LDH)轻度升高1例。然而，对这种疗法的耐受性很好。
Intravenous administration of sulbactam/ampicillin (SBT/ABPC) was evaluated in pediatric patients. The serum half-lives of both ABPC and SBT were approximately 1 hour following the intravenous injection or intravenous drip infusion of 20-35 mg/kg, and 30-50% of ABPC and 30-70% of SBT were recovered in the urine 6 hours. Cerebrospinal fluid concentrations of ABPC and SBT were 0.76 and 0.68 micrograms/ml, respectively, at 1 hour after intravenous drip infusion of the 58 mg/kg, and concentration ratios of the drugs in cerebrospinal fluid/serum were 6.39 and 5.71%, respectively. Thirty-four pediatric patients were treated with intravenous drip infusion of SBT/ABPC in doses ranging from 54 to 150 mg/kg divided into 3 times a day. The rate of clinical efficacy was 93.5% and the bacterial elimination rate was 92.3%. The synergistic activity of sulbactam with ampicillin was demonstrated against beta-lactamase-producing Staphylococcus aureus and Haemophilus influenzae isolated from patients in the present study. The side effects of SBT/ABPC were observed in 6 patients (5 diarrheas; 1 diarrhea with vomiting) out of 34 patients administered. Eosinophilia (2 patients) and a slight elevation of GOT (1 patient), GPT and LDH (1 patient) were observed. The tolerance to the therapy, however, was good.