Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children
Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children
复制标题
DOI：
10.1016/j.pediatrneurol.2007.01.012
复制
发表时间：
2007-06-01
影响因子：
3.8
通讯作者：
Kominsky, Matt
中科院分区：
文献类型：
--
作者：
Chez, Michael G.;Dowling, Tim;Kominsky, Matt
最近的报告暗示，在少数自闭症患者的中枢神经系统中细胞因子升高，报告了临床消退。这些研究没有关注肿瘤坏死因子-α作为炎症损伤的可能标志物。一系列的10名自闭症儿童进行了临床评估，他们的血清和脊髓液的炎症变化和可能的代谢疾病作为他们的神经系统评估的一部分。在所有研究的患者中，脑脊液肿瘤坏死因子-α水平的升高（平均1.04.10 pg/mL）显著高于同期血清水平（平均2.78 pg/mL）。脑脊液水平与血清水平的比值平均为53.7：1。该比率显著高于同时测量脑脊液和血清肿瘤坏死因子-α水平的其他病理状态报告的升高。这一观察结果可能提供了一个独特的洞察中枢神经系统炎症机制，可能有助于自闭症的发病，并可能作为一个潜在的临床标志物。对这一潜在的重要观察进行更多的对照研究可能是有价值的。(c)2007年，Elsevier Inc. All rights reserved.
Recent reports implicating elevated cytokines in the central nervous system in a small number of patients studied with autism have reported clinical regression. These studies have not focused on tumor necrosis factor-alpha as a possible marker for inflammatory damage. A series of 10 children with autism had clinical evaluation of their serum and spinal fluid for inflammatory changes and possible metabolic disease as part of their neurological evaluation. Elevation of cerebrospinal fluid levels of tumor necrosis factor-alpha was significantly higher (mean 1.04.10 pg/mL) than concurrent serum levels (mean 2.78 pg/mL) in all of the patients studied. The ratio of the cerebrospinal fluid levels to serum levels averaged 53.7:1. This ratio is significantly higher than the elevations reported for other pathological states for which cerebrospinal fluid and serum tumor necrosis factor-alpha levels have been simultaneously measured. This observation may offer a unique insight into central nervous system inflammatory mechanisms that may contribute to the onset of autism and may serve as a potential clinical marker. More controlled study of this potentially important observation may prove valuable. (c) 2007 by Elsevier Inc. All rights reserved.