Murine Models Demonstrate Distinct Vasculogenic and Cardiomyogenic cKit+ Lineages in the Heart.
Murine Models Demonstrate Distinct Vasculogenic and Cardiomyogenic cKit+ Lineages in the Heart.
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DOI：
10.1161/circresaha.115.308061
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发表时间：
2016-02-05
影响因子：
20.1
通讯作者：
Hare JM
中科院分区：
文献类型：
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作者：
Hatzistergos KE;Hare JM
继最近在小鼠中进行的两项遗传研究解决了心脏cKit+细胞的发育起源和再生活性之后，Sultana等人和Liu等人的另外两份报告提供了关于胚胎和成人心脏中cKit表达的进一步信息。在这里，我们综合了四种不同的c-kit模型的发现，以深入了解这种重要细胞类型的生物学。
Following two recent genetic studies in mice addressing the developmental origins and regenerative activity of cardiac cKit+ cells, two additional reports by Sultana et al. and Liu et al. provide further information on the expression of cKit in the embryonic and adult heart. Here we synthesize the findings from the four distinct c-kit models to gain insights into the biology of this important cell type.