Are adolescent idiopathic scoliosis and ankylosing spondylitis counter-opposing conditions? A hypothesis on biomechanical contributions predisposing to these spinal disorders.
Are adolescent idiopathic scoliosis and ankylosing spondylitis counter-opposing conditions? A hypothesis on biomechanical contributions predisposing to these spinal disorders.
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DOI：
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发表时间：
2003-09
影响因子：
3.7
通讯作者：
Alfonse T. Masi;Josephine L. Dorsch;Jacek Cholewicki
中科院分区：
文献类型：
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作者：
Alfonse T. Masi;Josephine L. Dorsch;Jacek Cholewicki
人体脊柱生物力学非常复杂，但尚未得到很好的理解，特别是在脊柱动态功能方面。将生物力学转化为疾病是困难的，特别是因为必须将因与果分开。诱发慢性脊柱疾病（如青少年特发性脊柱侧凸（AIS）或强直性脊柱炎（AS））发病的原发性动力学必须与继发性改变明确区分。这篇评论论述了可能诱发这些特发性疾病的主要生物力学。一个新的假设被提出，基于推论关于他们的对比肌肉动力学。该假设假定AIS与AS的固有肌肉张力相反。相反程度的脊柱稳定性可能导致AIS的弯曲畸形和AS的神经病变。在脊柱稳定性的多态谱中，一种情况被怀疑与另一种情况相反。
Human spinal biomechanics are profoundly complex and not well understood, especially in terms of the dynamic spine function. Translation of biomechanics to disease is difficult, particularly since cause must be separated from effect. Primary dynamics predisposing to the onset of chronic spinal disorders, e.g., adolescent idiopathic scoliosis (AIS) or ankylosing spondylitis (AS), must clearly be differentiated from secondary alterations. This commentary addresses primary biomechanics that may predispose to these idiopathic diseases. A novel hypothesis is proposed, based upon inferences regarding their contrasting muscular dynamics. The hypothesis postulates opposing inherent muscle tonicity in AIS versus AS. Converse degrees of spinal stability may predispose to the respective curvature deformities of AIS and the enthesopathy lesions of AS. One condition is suspected to counter-oppose the other, within a polymorphic spectrum of spinal stability.