Spatial clustering property and its self-similarity in membrane potentials of hippocampal CA1 pyramidal neurons for a spatio-temporal input sequence
Spatial clustering property and its self-similarity in membrane potentials of hippocampal CA1 pyramidal neurons for a spatio-temporal input sequence
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DOI：
10.1007/s11571-007-9026-9
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发表时间：
2007-10
影响因子：
3.7
通讯作者：
Y. Fukushima;M. Tsukada;I. Tsuda;Y. Yamaguti;S. Kuroda
中科院分区：
文献类型：
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作者：
Y. Fukushima;M. Tsukada;I. Tsuda;Y. Yamaguti;S. Kuroda
为了阐明海马CA3区时空序列信息对CA1区单个锥体细胞突触后膜电位的影响，通过一对电极向CA3区的Schaffer侧支传递时空刺激，用膜片钳记录方法记录突触后膜电位。运用“空间聚类”和“自相似”两个指标对投入产出关系进行了顺序分析。膜电位以与输入序列自相似的方式层次化地聚集。这一特性在两个和三个时间历史步骤中被显著观察到。此外，在两种不同的刺激条件下，弱电流刺激和强电流刺激下，这些特性都保持不变。实验结果与由Tsuda(Behav Brain Sci 24(5)：793-847,2001)和Tsuda和Kuroda(Jpn J Inust AppMath 18：249-258,2001；皮质动力学，第129-139页，Springer-Verlag，2004)报道的Cantor编码的理论结果相关讨论。
To clarify how the information of spatiotemporal sequence of the hippocampal CA3 affects the postsynaptic membrane potentials of single pyramidal cells in the hippocampal CA1, the spatio-temporal stimuli was delivered to Schaffer collaterals of the CA3 through a pair of electrodes and the post-synaptic membrane potentials were recorded using the patch-clamp recording method. The input–output relations were sequentially analyzed by applying two measures; “spatial clustering” and its “self-similarity” index. The membrane potentials were hierarchically clustered in a self-similar manner to the input sequences. The property was significantly observed at two and three time-history steps. In addition, the properties were maintained under two different stimulus conditions, weak and strong current stimulation. The experimental results are discussed in relation to theoretical results of Cantor coding, reported by Tsuda (Behav Brain Sci 24(5):793–847, 2001) and Tsuda and Kuroda (Jpn J Indust Appl Math 18:249–258, 2001; Cortical dynamics, pp 129–139, Springer-Verlag, 2004).