EFFECT OF ACUTE AND LONG-TERM SMOKING ON MYOCARDIAL BLOOD-FLOW AND FLOW RESERVE
EFFECT OF ACUTE AND LONG-TERM SMOKING ON MYOCARDIAL BLOOD-FLOW AND FLOW RESERVE
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DOI：
10.1161/01.cir.91.12.2891
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发表时间：
1995-06-15
期刊：
影响因子：
37.8
通讯作者：
SCHELBERT, H
中科院分区：
文献类型：
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作者：
CZERNIN, J;SUN, K;SCHELBERT, H
研究背景吸烟是冠心病和心脏性猝死的主要可预防危险因素。然而，急性和长期吸烟对冠状动脉血管扩张能力和心肌血流储备的影响尚未在人类中得到量化。方法与结果：在基线条件下(反映长期吸烟的影响)和短期吸烟期间，12名吸烟者(男性10名，女性2名；平均年龄27±4岁)在静息状态和双嘧达莫引起的充血(0.56 mg/kg)时，通过正电子发射断层扫描和二室模型，对短期和长期吸烟的影响进行了量化。12名性别和年龄匹配的非吸烟者作为对照对象。吸烟使安静时心率-压力乘积由7525+/-1290增加到9160+/-1125(P
Background Cigarette smoking is a major preventable risk factor for coronary artery disease and sudden cardiac death. However, the effect of acute and long-term cigarette smoking on coronary vasodilatory capacity and myocardial flow reserve has not been quantified in humans.Methods and Results To examine the effect of short-term and long-term smoking, myocardial blood flow was quantified at rest and during dipyridamole-induced hyperemia (0.56 mg/kg) in 12 smokers (10 males and 2 females; mean age, 27 +/- 4 years) under baseline conditions (reflecting the effect of longterm smoking) and during short-term cigarette smoking with N-13 ammonia, positron emission tomography, and a two-compartment model. Twelve sex- and age-matched nonsmokers served as control subjects. Smoking significantly increased the rate-pressure product at rest from 7525 +/- 1290 to 9160 +/- 1125 (P