RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions
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DOI：
10.1039/b716357f
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发表时间：
2008-01-01
影响因子：
--
通讯作者：
Song, Si-Young
中科院分区：
文献类型：
--
作者：
Iwashita, Shintaro;Song, Si-Young
Ras及其GTP酶激活蛋白（GAP）是细胞外配体的重要调节因子。在过去的二十年中，在信号转导的研究过程中已经阐明了关于这些调节剂的信息。RasGAP如p120 GAP和神经纤维蛋白作为Ras的“负”调节因子或效应因子的作用已被广泛研究。越来越多的证据表明，这些分子是细胞外刺激的重要调节剂，用于维持细胞功能的稳态。本概要从稳态的角度强调了RasGAP的细胞功能及其信号特征，包括我们最近发现的GAP活性下调的R-RasGAP突变小鼠的表型。
Ras and its GTPase activating proteins ( GAPs) are among the crucial regulators of extracelluar ligands. Information about these regulators has been elucidated during the course of studies in signal transduction over the last two decades. RasGAPs such as p120GAP and neurofibromin have been studied extensively for their roles as either "negative'' regulators or effectors of Ras. Accumulating evidence suggests that these molecules are crucial regulators of extracellular stimuli that serve to maintain the homeostasis of cellular functions. This compendium highlights cellular functions of RasGAPs and their signaling characteristics from the viewpoint of homeostasis, including our recent finding of the phenotype of R-RasGAP mutant mice whose GAP activity is down-regulated.