Lifestyle and nutritional determinants of bioavailable androgens and related hormones in British men
Lifestyle and nutritional determinants of bioavailable androgens and related hormones in British men
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DOI：
10.1023/a:1015238102830
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发表时间：
2002-05-01
影响因子：
2.3
通讯作者：
Key, TJ
中科院分区：
文献类型：
--
作者：
Allen, NE;Appleby, PN;Key, TJ
目的：探讨男性血清生物可利用雄激素及其相关激素的生活方式和营养决定因素。方法：本研究以 696 名营养摄入量不同的男性为样本，通过问卷调查评估其饮食和生活方式特征，并使用免疫测定法测量血清性激素。结果：70 岁或以上男性的睾酮水平降低 12%，游离睾酮 (FT) 和雄烷二醇降低 40%葡萄糖醛酸（A-二醇-g）浓度高于20-29岁男性。相反，与最低年龄组相比，最大年龄组的性激素结合球蛋白 (SHBG) 和黄体生成素 (LH) 浓度分别高出 90% 和 49%。与 BMI < 20 kg/m(2) 的男性相比，体重指数 (BMI) 超过 30 kg/m(2) 的男性睾酮水平降低 30%，性激素结合球蛋白 (SHBG) 降低 45%，LH 降低 22%，FT 浓度降低 5%。相反，与最低 BMI 类别相比，最高 BMI 类别的 A-diol-g 浓度高出 15%。调整 BMI 后，高腰围还与睾酮和 SHBG 浓度降低 12% 相关。与从不吸烟的人相比，每天吸 10 支以上香烟的睾酮水平升高 15%，性激素结合球蛋白 (SHBG) 水平升高 22%，黄体生成素 (LH) 浓度升高 17%； FT 和 A-diol-g 与吸烟无关。与不运动相比，每周 3 小时以上的剧烈运动与睾酮水平升高 11% 和 SHBG 浓度升高 16% 相关，而 LH、FT 和 A-diol-g 与剧烈运动无关。尽管饱和脂肪摄入量与 SHBG 呈负相关（r = -0.10；p = 0.01），酒精摄入量与 A-diol-g 呈正相关（r = 0.11；p = 0.004），但饮食因素与激素的相关性并不强。饮食因素与睾酮、FT 或 LH 无关。结论：年龄是血清生物可利用雄激素的最强决定因素。 BMI 和一些生活方式和饮食因素会影响 SHBG 和睾酮浓度，但与 FT 没有很强的相关性，这表明体内平衡是有效的。除了 BMI 和酒精的影响外，A-diol-g 与 FT 的关联性大致相似。
Objective: To investigate the lifestyle and nutritional determinants of serum bioavailable androgens and their related hormones in men.Methods: This study is based on a sample of 696 men with a wide range of nutrient intakes, whose diet and lifestyle characteristics were assessed with a questionnaire and serum sex hormones measured using immunoassays.Results: Men aged 70 years or older had 12% lower testosterone and 40% lower free-testosterone (FT) and androstanediol glucuronide (A-diol-g) concentrations than men who were 20-29 years of age. Conversely, sex hormone-binding globulin (SHBG) and luteinizing hormone (LH) concentrations were 90% and 49% higher in the oldest age group compared with the lowest, respectively. Men who had a body mass index (BMI) of 30+ kg/m(2) had 30% lower testosterone, 45% lower SHBG, 22% lower LH and 5% lower FT concentrations compared with men with a BMI of < 20 kg/m(2). Conversely, A-diol-g concentration was 15% higher in the highest BMI category compared with the lowest. A high waist circumference was further associated with a 12% lower testosterone and SHBG concentration, after adjusting for BMI. Compared with never-smokers, smoking 10+ cigarettes/day was associated with 15% higher testosterone, 22% higher SHBG and 17% higher LH concentrations; FT and A-diol-g were not associated with smoking. Compared with no exercise, vigorous exercise of 3+ hours/week was associated with 11% higher testosterone and 16% higher SHBG concentrations, whilst LH, FT, and A-diol-g were not associated with vigorous exercise. Dietary factors were not strongly associated with hormones, although saturated fat intake was negatively associated with SHBG (r = -0.10; p = 0.01) and alcohol intake was positively associated with A-diol-g (r = 0.11; p = 0.004). No dietary factors were associated with testosterone, FT, or LH.Conclusions: Age is the strongest determinant of serum bioavailable androgens. BMI and some lifestyle and dietary factors influence SHBG and testosterone concentrations, but have no strong association with FT, suggesting that homeostasis is effective. A-diol-g shows broadly similar associations to FT, with the exception of the effect of BMI and alcohol.