Glucan-induced enhancement of host resistance in experimental intraabdominal sepsis.
Glucan-induced enhancement of host resistance in experimental intraabdominal sepsis.
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实验性腹内脓毒症中葡聚糖诱导的宿主抵抗力增强。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
C. Nord
中科院分区：
文献类型：
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作者：
G. Lahnborg;K. Hedström;C. Nord
葡聚糖是酿酒酵母细胞壁的一种1 - 3-多糖苷成分，评价其改变腹腔内脓毒症大鼠存活率的能力。在四组中，每组15只大鼠，通过给动物咀嚼肉类，将细菌植物群变成人类的。腹腔内脓毒症的诱导是通过切除1cm的肠并通过一层端端吻合重建肠连续性后将其重新植入腹腔内。给大鼠注射葡聚糖或等容盐水或苄青霉素或葡聚糖加苄青霉素。结果表明，在用葡聚糖或苄青霉素治疗的组与仅用盐水治疗的组之间，死亡率没有显著差异。然而，用葡聚糖加苄青霉素治疗的组与仅给予盐水的对照组显著不同。细菌植物群似乎不受葡聚糖给药的影响。它的结论是，葡聚糖有一个明确的影响，诱导腹膜炎的大鼠的存活率，可能是通过增强活动的网状内皮系统-一个重要的组成部分，总的主机电阻。
Glucan, a 1-3-polyglucosidic component of the cell wall of Saccharomyces cerevisiae, was evaluated for its ability to alter survival in rats with induced intraabdominal sepsis. In four groups, each of 15 rats, the bacteriological flora was changed into that of humans by giving the animals a meat chew. Intraabdominal sepsis was induced by resecting 1 cm of the intestine and reimplanting it in the abdominal cavity after reestablishing the intestinal continuity by one-layer end-to-end anastomosis. The rats were injected with either glucan or isovolumetric saline or benzylpenicillin or glucan plus benzylpenicillin. The results indicate no significant difference in mortality rate between the groups treated with either glucan or benzylpenicillin on the one hand and, on the other, the group given saline alone. However, the group treated with glucan plus benzylpenicillin differed significantly from the control group given just saline. The bacterial flora did not seem to be influenced by glucan administration. It is concluded that glucan has a clear effect on the survival rate of rats with induced peritonitis, probably by enhancing the activities of the reticuloendothelial system--an important part of the total host resistance.