Supramolecular and biomacromolecular enhancement of metal-free magnetic resonance imaging contrast agents
Supramolecular and biomacromolecular enhancement of metal-free magnetic resonance imaging contrast agents
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DOI：
10.1039/c9sc05510j
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发表时间：
2020-02-28
期刊：
影响因子：
8.4
通讯作者：
Gassensmith, Jeremiah J.
中科院分区：
文献类型：
--
作者：
Lee, Hamilton;Shahrivarkevishahi, Arezoo;Gassensmith, Jeremiah J.
磁共振成像的许多造影剂都是基于钆的，但副作用限制了它们在某些患者中的使用。有机自由基造影剂（ORCA）是潜在的替代品，但在生理条件下迅速减少，并且作为单分子造影剂具有低弛豫率。在本文中，我们使用超分子策略，其中葫芦[8]脲以纳摩尔亲和力与ORCA结合，并保护它们免受生物还原剂的影响，以在体内产生稳定的自由基。我们进一步克服了弱对比度通过共轭这种复合物的表面上的自组装的生物大分子来自烟草花叶病毒。
Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further overcame the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.