Plasma and urinary catecholamines and their metabolites in chronic renal failure.
Plasma and urinary catecholamines and their metabolites in chronic renal failure.
复制标题
慢性肾功能衰竭中的血浆和尿儿茶酚胺及其代谢物。
作者：
R. Darwish;A. Elias;N. Vaziri;M. Pahl;D. Powers;J. Stokes
慢性肾衰竭 (CRF) 对儿茶酚胺及其代谢物的血浆浓度和尿排泄的影响在 14 名肌酐清除率为 19 至 77 mL/min 的不同程度慢性肾衰竭患者中进行了研究。将结果与一组年龄匹配的正常对照中获得的结果进行比较。与年龄匹配的正常对照相比，CRF 患者的血浆儿茶酚胺浓度显着较高（456.9 +/- 303.1 vs 278.5 +/- 81.1 pg/mL）。尿变肾上腺素（0.6 +/- 0.6 mg/g 肌酐）和香草扁桃酸（VMA）（6.6 +/- 4.2 mg/g 肌酐）均在正常范围内。肌酐清除率与尿变肾上腺素和 VMA 排泄量或血浆儿茶酚胺浓度之间没有发现显着相关性。我们的观察表明，尽管肌酐清除率下降，但尿 VMA 和变肾上腺素测定是肾功能受损患者嗜铬细胞瘤的有效筛查试验。然而，血浆儿茶酚胺浓度随着肾功能的下降而中度升高。
The effect of chronic renal failure (CRF) on the plasma concentration and urinary excretion of catecholamines and their metabolites was studied in 14 patients with varying degrees of chronic renal failure who had creatinine clearances of 19 to 77 mL/min. The results were compared with those obtained in a group of age-matched normal controls. Plasma catecholamine concentrations were significantly higher in the CRF patients compared with age-matched normal controls (456.9 +/- 303.1 v 278.5 +/- 81.1 pg/mL). The urinary metanephrine (0.6 +/- 0.6 mg/g creatinine) and vanillylmandelic acid (VMA) (6.6 +/- 4.2 mg/g creatinine) were within the normal range. No significant correlations were found between creatinine clearance and urinary metanephrine and VMA excretion or with the plasma catecholamine concentrations. Our observations indicate that, despite the decrease in creatinine clearance, urinary VMA and metanephrine determinations are valid screening tests for pheochromocytoma in patients with compromised renal function. Plasma catecholamine concentrations, however, show moderate elevation with decreasing renal function.