H-1 AND C-13 NUCLEAR MAGNETIC-RESONANCE SPECTRA OF PHENYLACETIC ACID-DERIVATIVES
H-1 AND C-13 NUCLEAR MAGNETIC-RESONANCE SPECTRA OF PHENYLACETIC ACID-DERIVATIVES
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DOI：
10.1080/00387018008065071
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发表时间：
1980-01-01
影响因子：
1.7
通讯作者：
FINEGOLD, H
中科院分区：
文献类型：
--
作者：
MANDAVA, N;FINEGOLD, H
通过选择性辐照苯乙酸甲酯，获得了-CH 2COOCH 3基团的芳香族13 C取代基常数。这样得到的值是用于精炼的文献值的-OH和-OCH 3取代基常数和分配所有的芳香族线在六个衍生异构体。对于间位异构体和对位异构体，所有芳香族13 C共振的计算值和实验值均在0.2 ppm以内。为了评价生物重要的苯乙酸衍生物的快速定性分析方法，获得和分配的1H共振，和苄基亚甲基化学位移被证明是这些衍生物的芳香族异构体的具体诊断。
The aromatic13C substituent constant for the -CH2COOCH3group is obtained by selectively irradiating phenylacetic acid methyl ester. The value so obtained is used for refining the literature values of the -OH and -OCH3substituent constants and for assigning all the aromatic lines in six derivative isomers. Formetaandparaisomers, calculated and experimental values for all the aromatic13C resonances are within 0.2 ppm. For purposes of evaluating a rapid qualitative analytical method for the biologically important phenylacetic acid derivatives, the1H resonances are obtained and assigned, and the benzylic methylene chemical shifts are shown to be specifically diagnostic of aromatic isomerism for these derivatives.