Clustering of six human 11p15 gene homologs within a 500-kb interval of proximal mouse chromosome 7.
Clustering of six human 11p15 gene homologs within a 500-kb interval of proximal mouse chromosome 7.
复制标题
六个人类 11p15 基因同源物在小鼠近端 7 号染色体 500 kb 间隔内聚类。
DOI：
10.1006/geno.1994.1623
复制
发表时间：
1994
期刊：
影响因子：
4.4
通讯作者：
Johnson,D
中科院分区：
文献类型：
--
作者：
Stubbs,L;Rinchik,EM;Goldberg,E;Rudy,B;Handel,MA;Johnson,D
Homologs of genes mapping to human chromosome 11p15 are located in three distinct, widely separated regions of mouse chromosome 7 (Mmu7). To date, six genes have been localized to the most proximal HSA11p15/Mmu7 homology region, includingLdh3(encoding lactate dehydrogenase C),Ldh1(lactate dehydrogenase A),Myod1(myogenic differentiation factor-1),Tph(tryptophan hydroxylase),Saa1(serum amyloid-A-1), andKcnc1(encoding a Shaw-type voltage-gated potassium channel). To define the overall size and organization of this region of Mmu7, we have established a long-range physical map including the murineLdh1,Ldh3,Saa,Tph,Kcnc1, andMyod1genes. Our results demonstrate that these six genes are physically clustered and are distributed throughout a 500-kb interval located just proximal of the pink-eyed dilution (p) locus. These data, together with recent mapping studies within the related region of HSA11p15, demonstrate that gene content and organization within this proximal homology segment have been highly conserved throughout evolution.
