Epidemiology of medications use in pregnancy.
Epidemiology of medications use in pregnancy.
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DOI：
10.1053/j.semperi.2015.08.002
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发表时间：
2015-11
影响因子：
3.4
通讯作者：
Costantine MM
中科院分区：
文献类型：
--
作者：
Ayad M;Costantine MM
怀孕期间使用处方药和非处方药的情况正在增加。许多妇女在年龄较大时怀孕，并且已有需要药物治疗的疾病。此外，怀孕与身体几乎每个器官的生理变化有关，影响药物的药代动力学和药效学。尽管如此，孕妇仍然被认为是治疗孤儿，因为目前大多数治疗方法从未在怀孕期间进行过研究。本综述的目的是综合有关妊娠期药物使用的流行病学和药物研究现状的现有信息，以强调妊娠期药物研究的必要性。
The use of prescribed and over-the-counter medications in pregnancy is on the rise. Many women become pregnant at an older age and with pre-existing medical conditions that require pharmacotherapy. In addition, pregnancy is associated with profound changes in the physiology of virtually every organ in the body, which affect medications’ pharmacokinetics and pharmacodynamics. Despite all of these, pregnant women are still considered therapeutic orphans as the majority of current therapeutics were never studied in pregnancy. The goals of this review are to synthesize the available information regarding the epidemiology of medications use and the state of drug research in pregnancy, in an effort to highlight the need for pharmacologic research in pregnancy.