Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering.
Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering.
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DOI：
10.3390/s151229848
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发表时间：
2015-12-10
期刊：
影响因子：
--
通讯作者：
Forte G
中科院分区：
文献类型：
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作者：
Perestrelo AR;Águas AC;Rainer A;Forte G
生物医学技术的最新进展主要与生物学与微工程的融合有关。例如，微流控装置现在在大多数研究中心、诊所和医院都很常见，作为药物输送、特定分析物监测和医疗诊断的强大工具，有助于更准确的研究和治疗。最值得注意的是，在微工程平台内整合细胞化结构，可以重现复杂组织和器官的生理和病理状况。所谓的“器官芯片”技术代表了先进体外模型领域的新途径，有可能彻底改变目前的药物筛选和毒理学研究方法。本文综述了近年来基于微流控技术的人体芯片器件的研究进展，探讨了微流控技术在生物医学领域的应用前景。
Recent advances in biomedical technologies are mostly related to the convergence of biology with microengineering. For instance, microfluidic devices are now commonly found in most research centers, clinics and hospitals, contributing to more accurate studies and therapies as powerful tools for drug delivery, monitoring of specific analytes, and medical diagnostics. Most remarkably, integration of cellularized constructs within microengineered platforms has enabled the recapitulation of the physiological and pathological conditions of complex tissues and organs. The so-called “organ-on-a-chip” technology, which represents a new avenue in the field of advanced in vitro models, with the potential to revolutionize current approaches to drug screening and toxicology studies. This review aims to highlight recent advances of microfluidic-based devices towards a body-on-a-chip concept, exploring their technology and broad applications in the biomedical field.