A functional anatomy of anticipatory anxiety
A functional anatomy of anticipatory anxiety
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DOI：
10.1006/nimg.1999.0407
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发表时间：
1999-06-01
期刊：
影响因子：
5.7
通讯作者：
Dolan, R
中科院分区：
文献类型：
--
作者：
Chua, P;Krams, M;Dolan, R
预期焦虑是面向未来的认知状态、负面情绪和自主唤醒的复杂组合。使用预期电击和运动学习任务的双任务范例来检查与分散注意力的运动任务对焦虑中认知状态的调节相关的神经激活模式的变化。我们使用正电子发射断层扫描 (PET) 和 O-15-水来测量 10 名健康男性志愿者的局部脑血流 (rcbf)。使用 2 x 2 因子设计（电击与无电击）x（低干扰与高干扰），每个条件进行 3 次扫描。对每个受试者进行 12 次 PET 扫描，其中 6 次扫描中，受试者接受了电击。在所有扫描中，受试者还同时执行运动重复（低分心）或学习（高分心）任务。还收集了皮肤电导（GSR）、斯皮尔伯格状态和特质焦虑量表（STAI）以及自我报告数据。在电击和无电击条件之间的比较中，主要发现是左侧岛叶（-38,8,8）（z = 4.85，P < 0.05 校正）中的 rcbf 增加，而右侧岛叶中的同源区域处于较低阈值（z = 3.20，P = 0.001 未校正）。其他被激活的区域包括右侧颞上沟、左侧梭状皮质和左侧前扣带回。使用 STAI 状态评分作为感兴趣的协变量，在左眶额皮质、左岛叶和左前扣带皮层中观察到与 rCBF 显着相关。通过 STAI、自我报告、GSR 反应或 PET 数据的交互分析来测量，没有显着的分心效应。这些发现支持旁边缘结构作为预期焦虑的神经基质的作用。未能证明分散注意力任务的行为和神经生理学变化可能反映出电击引起的焦虑适度增加、分散注意力任务相对简单以及样本量较小。 (C)，1999学术出版社。
Anticipatory anxiety is a complex combination of a future-oriented cognitive state, negative affect, and autonomic arousal. A dual-task paradigm of anticipation of electric shocks and a motor-learning task was used to examine the changes in neural patterns of activation associated with modulation of the cognitive state in anxiety by a distracting motor task. We used positron emission tomography (PET) and O-15-water to measure regional cerebral blood how (rcbf) in 10 healthy male volunteers. A 2 x 2 factorial design(shock vs no shock) x (low vs high distraction) was used with three scans per condition. Twelve PET scans were performed on each subject, In six of these scans, subjects were given electric shocks. In all scans, subjects also simultaneously performed a motor repetition (low distraction) or learning (high distraction) task. Galvanic skin conductance (GSR), Spielberger State and Trait Anxiety Inventory (STAI), and self-report data were also collected. In comparisons between the shock and no-shock conditions, the main finding was of increased rcbf in the left insula (-38,8,8) (z = 4.85, P < 0.05 corrected) and a homologous area in the right insula at a lower threshold(z = 3.20, P = 0.001 uncorrected). Other areas activated were the right superior temporal sulcus, left fusiform, and left anterior cingulate. Using the STAI-state scores as a covariate of interest, significant correlations with rCBF were seen in the left orbitofrontal cortex, left insula, and left anterior cingulate cortex. There was no significant distraction effect as measured by the STAI, self-report, GSR response or interactional analysis of the PET data. These findings support the role of paralimbic structures as neural substrates of anticipatory anxiety. The failure to demonstrate behavioral and neurophysiological changes with the distracter task may reflect the modest increases in anxiety with the shock, the relatively simple distracter task, and small sample size. (C),1999 Academic Press.