Is pregnancy in diabetic women associated with folate deficiency?
Is pregnancy in diabetic women associated with folate deficiency?
复制标题
DOI：
10.2337/diacare.22.7.1017
复制
发表时间：
1999-07
期刊：
影响因子：
16.2
通讯作者：
Jeremy S. Kaplan;Saba Iqbal;B. England;C. M. Zawacki;W. Herman
中科院分区：
文献类型：
--
作者：
Jeremy S. Kaplan;Saba Iqbal;B. England;C. M. Zawacki;W. Herman
目的确定妊娠期糖尿病妇女叶酸代谢是否与妊娠期非糖尿病妇女有显著差异，从而使其后代具有重大先天性畸形。研究设计和方法：共有31名妊娠糖尿病妇女和54名妊娠非糖尿病对照组在其首次产前访视。在控制叶酸补充后，测定并比较膳食叶酸摄入量、血清叶酸、红细胞叶酸、尿叶酸和同型半胱氨酸。在糖尿病妇女中，叶酸代谢和血糖控制参数之间的关系也进行了评估。结果：补充叶酸后，妊娠糖尿病和非糖尿病妇女的叶酸代谢指标无显著差异。此外，在糖尿病女性中，叶酸代谢和血糖控制参数之间没有相关性。结论：叶酸代谢异常似乎不发生在妊娠糖尿病妇女。叶酸代谢紊乱不太可能解释糖尿病母亲的婴儿中主要畸形的较高发生率。这些结果并没有降低围受孕期补充叶酸的重要性，也没有排除其他可能限制胚胎使用叶酸的情况，从而导致先天性异常。
OBJECTIVE To determine whether folate metabolism in pregnant diabetic women is significantly different from that in pregnant nondiabetic women, thus predisposing them to having offspring with major congenital anomalies. RESEARCH DESIGN AND METHODS A total of 31 pregnant diabetic women and 54 pregnant nondiabetic control subjects were studied at their first prenatal visits. Dietary folate intake, serum folate, red blood cell folate, urinary folate, and homocysteine were measured and compared after controlling for folate supplementation. Among diabetic women the relationships among parameters of folate metabolism and glycemic control were also assessed. RESULTS There were no significant differences between the pregnant diabetic and non-diabetic women for any measures of folate metabolism after accounting for folate supplementation. In addition, among diabetic women, there were no associations among parameters of folate metabolism and glycemic control. CONCLUSIONS Abnormal folate metabolism does not appear to occur in pregnant diabetic women. It is unlikely that deranged folate metabolism explains the higher incidence of major anomalies in infants of diabetic mothers. These results do not diminish the importance of periconception folate supplementation or preclude other possible scenarios that could restrict folate use by the embryo, leading to congenital anomalies.