Involvement of lactate transport in two object recognition tasks that require either the hippocampus or striatum.
Involvement of lactate transport in two object recognition tasks that require either the hippocampus or striatum.
复制标题
乳酸转运参与两个需要海马体或纹状体的物体识别任务。
DOI：
10.1037/bne0000304
复制
发表时间：
2019
影响因子：
1.9
通讯作者：
Gold,PaulE
中科院分区：
文献类型：
--
作者：
Korol,DonnaL;Gardner,RobertS;Tunur,Tumay;Gold,PaulE
Growing evidence indicates that hippocampal lactate, released from astrocytes, is an important regulator of learning and memory processing. This study evaluated the selective involvement of hippocampal and striatal lactate in two object recognition tasks. The tasks tested recognition memory after a change in location of two target objects (double object location; dOL) or after replacement of familiar targets with two new objects set in the original locations (double object replacement; dOR). Rats received three study sessions across which exploration times decreased. The recognition index was the change in exploration time of both objects on a test trial from the exploration times on the final study trial. We first verified a double dissociation between hippocampus and striatum across these tasks. The sodium channel blocker, lidocaine, was infused into one of the two brain regions after the study sessions and before the test trial. To test the role of neuronal lactate in recognition memory, an inhibitor of the neuronal lactate transporter, α-cyano-4-hydroxycinnamate (4-CIN), was similarly infused. For both drugs, infusions into the hippocampus but not the striatum impaired recognition in the dOL, whereas infusions into the striatum but not hippocampus impaired recognition in the dOR. The findings obtained with 4-CIN demonstrate for the first time the importance of neuronal lactate uptake in the hippocampus and the striatum for object recognition memory processing.
