Effects of monoamine reuptake blockade on ponto-geniculo-occipital wave activity.
Effects of monoamine reuptake blockade on ponto-geniculo-occipital wave activity.
复制标题
单胺再摄取阻断对脑桥膝枕波活动的影响。
DOI：
10.1016/0028-3908(90)90149-l
复制
发表时间：
1990
影响因子：
4.7
通讯作者：
Morrison,AR
中科院分区：
文献类型：
--
作者：
Ross,RJ;Ball,WA;Levitt,DR;Gresch,PJ;Morrison,AR
去甲肾上腺素 (NE) 和血清素 (5HT) 可能会抑制脑桥膝枕叶 (PGO) 波的产生。给猫施用地昔帕明 (DMI) 或舍曲林 (SER:1S,4S-N-甲基-4-(3,4-二氯苯基)-1,2,3,4-十六氢-1-萘胺) 2.5 周，分别探索去甲肾上腺素能和血清素能机制。将安慰剂天数与用药第一天以及用药 2.5 周后的天数（慢性）进行比较。慢性 DMI 或 SER 会显着降低 REM 睡眠期间和之前过渡期的 PGO 率。猫的 PGO 波类似于在清醒时伴随对强烈或新奇刺激的警报的波。人类抑郁症具有过度警觉的特征；抗抑郁药物对 PGO 波的抑制可能与临床抗抑郁作用有关。
Norepinephrine (NE) and serotonin (5HT) likely inhibit the generation of ponto-geniculo-occipital (PGO) waves. Either desipramine (DMI) or sertraline (SER:1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-cetrahydro-1-naphthylamine) was administered in the cat for 2.5 weeks to probe noradrenergic and serotonergic mechanisms, respectively. Placebo days were compared with the first day of drug and with days that followed 2.5 weeks of drug (chronic). PGO rates during REM sleep and the preceding transition period were significantly decreased by either chronic DMI or SER. Cat PGO waves resemble waves that accompany alerting to intense or novel stimuli in wakefulness. Depressive disorders in humans have features of hyperarousal; PGO wave suppression by antidepressant drugs may relate to clinical antidepressant actions.