Mechanisms determining safety and performance of brain stimulating electrodes.
Mechanisms determining safety and performance of brain stimulating electrodes.
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决定大脑刺激电极的安全性和性能的机制。
DOI：
10.1109/iembs.2009.5334136
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Gluckman,BruceJ
中科院分区：
文献类型：
--
作者：
Andre,DanaLynn;Shanmugasundaram,Balaji;Mason,Jonathan;Drapaca,Corina;Gluckman,BruceJ
电流被广泛用于与神经系统相互作用或刺激神经系统。从器械到组织的电流传导在电极-组织界面处通过电容电荷和电化学介导。该电荷通过容量是频率依赖性的。虽然已经为高频建立了安全参数，但尚未完全确定新型材料和脉冲频率明显低于100 Hz的安全性。我们对神经系统在低频（<<100 Hz）下的电荷传递的安全参数和性能非常感兴趣。我们提出了一个可视化的研究过程中的pH值的电沉积氧化铱电极的电荷通过。观察到从电极表面延伸数百微米的清晰反应扩散波。
Electrical current is widely used to interact with or stimulate neural systems. Current transduction from device to tissue is mediated at the electrode-tissue interface by capacitive charge and electrochemistry. This charge-passing-capacity is frequency dependent. While safety parameters have been established for high-frequencies, safety has not been fully determined for novel materials and pulse frequencies significantly lower than 100 Hz. We are explicitly interested in safety parameters and performance of charge passing at low frequencies (<<100 Hz) for neural systems. We present a visual study of pH during charge passing for electrodeposited iridium oxide electrodes. Clear reaction-diffusion waves are observed that extend many hundreds of micrometers from the electrode surface.