Effect of apolipoprotein E genotype on hippocampal volume loss in aging healthy women
Effect of apolipoprotein E genotype on hippocampal volume loss in aging healthy women
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DOI：
10.1212/wnl.57.12.2223
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发表时间：
2001-12-26
期刊：
影响因子：
9.9
通讯作者：
Sunderland, T
中科院分区：
文献类型：
--
作者：
Cohen, RM;Small, C;Sunderland, T
目的：确定APOE基因单个epsilon4等位基因的存在是否与健康女性在60岁时海马体积损失率增加或认知能力下降有关。方法：9名APOE-epsilon4等位基因阴性（平均年龄+/- SD， 60.6 +/- 10.2岁）和16名APOE-epsilon4等位基因阳性（平均年龄+/- SD 55.1 +/- 6.0岁）的健康女性在进入研究时（基线）和2年后进行了神经认知测试和MRI。神经认知测试包括Buschke-Fuld自由回忆、语言流畅性测试、Rey图形测试、韦氏记忆量表（修订版）和韦氏成人智力调查（修订版）块设计。海马体积的测定是基于手工勾画矢状面切片，辅以轴位、冠状面和高分辨率124层全脑扫描的三维视图；扫描结果由1.5特斯拉扫描仪获得，采用t1加权三维梯度回波序列（TR/TE/翻转角，24 msec/3 msec/30度）。结果：APOE-epsilon4等位基因阳性组海马体积年变化百分比（平均+/- SD， 2.32 +/- 1.75%）大于APOE-epsilon4等位基因阴性组（平均+/- SD， 0.77 +/- 1.02%, t = 2.41, p < 0.03，双尾检验）。两组在任何认知测量方面都没有显著差异，海马体积损失与上述任何认知测量的变化都没有相关性。结论：APOE-epsilon4等位基因的存在与健康女性在60岁时海马体积损失的增加率有关，而这与任何可检测到的记忆变化无关。
Objective: To determine whether the presence of a single epsilon4 allele of the APOE gene is associated with an increased rate of hippocampal volume loss or decline in cognition in healthy women in their sixth decade of life. Methods: Nine APOE-epsilon4 allele-negative (mean age +/- SD, 60.6 +/- 10.2 years) and 16 APOE-epsilon4 allele-positive (mean age +/- SD 55.1 +/- 6.0 years) healthy women underwent neurocognitive testing and MRI at the time of entry into the study (baseline) and 2 years later. Neurocognitive testing consisted of the Buschke-Fuld Free Recall, verbal fluency tests, the Rey Figure Test, the Wechsler Memory Scale-Revised, and the Wechsler Adult Intelligence Survey-Revised Block Design. Hippocampal volume determinations were based on manual outlining of sagittal slices aided by axial, coronal, and three-dimensional views of high-resolution 124-slice whole-brain scans; the scans were obtained with a 1.5-tesla scanner using a T1-weighted three-dimensional gradient echo sequence with RF spoiling (TR/TE/flip angle, 24 msec/3 msec/30 degrees). Results: The percent change in hippocampal volume per year was greater in the A-POE-epsilon4 allele-positive group (mean +/- SD, 2.32 +/- 1.75%) than in the APOE-epsilon4 allele-negative group (mean +/- SD, 0.77 +/- 1.02%; t = 2.41; p < 0.03, two-tailed test). There were no significant differences between the two groups in terms of any of the cognitive measures, and hippocampal volume loss was not correlated with changes in any of the above-mentioned cognitive measures. Conclusions: The presence of a single APOE-epsilon4 allele is associated with an increased rate of hippocampal volume loss in healthy women in their sixth decade of life that is not related to any detectable memory changes.