Utility assessment among patients with dry eye disease
Utility assessment among patients with dry eye disease
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DOI：
10.1016/s0161-6420(03)00462-7
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发表时间：
2003-07-01
期刊：
影响因子：
13.7
通讯作者：
Sumner, W
中科院分区：
文献类型：
--
作者：
Schiffman, RM;Walt, JG;Sumner, W
目的：确定干眼病的效用（患者偏好）。设计：调查研究。受试者：56例轻度、中度或重度干眼症患者，由亨利福特医疗保健系统眼科护理服务部的眼科医生治疗。采用时间权衡法（TTO）完成交互式软件效用评估问卷。效用得分的尺度是这样的，得分1.0 =完美健康，0 =死亡。使用临床参数和医生/患者评估对干眼严重程度进行独立分类。全球健康状况、视觉功能和眼部症状通过简表36健康调查、25项美国国家眼科研究所视觉功能问卷（NEI VFQ-25）和眼表疾病指数调查工具进行评估。主要结局指标：干眼严重程度的效用评分。将这些效用与其他疾病状态报告的效用进行比较。与一般和视力相关的健康状况测量进行了相关性分析。结果：56例患者完成效用评估，可靠性可接受。TTO对中度（0.78）和重度干眼症（0.72）的平均效用与中度（0.75）和更严重（III/IV级）心绞痛（0.71）的历史报告相似。效用得分与NEI VFQ-25综合得分相关（p 0.32; p = 0.037），并与其他健康措施的组成部分相关。结论：更严重干眼症的效用在III/IV级心绞痛（0.71）等被广泛认为是降低健康效用的条件范围内。我们的研究结果强调了与其他疾病相比，干眼症对患者的影响有多大。(C) 2003年由美国眼科学会出版。
Purpose: To determine utilities (patient preferences) for dry eye disease.Design: Survey study.Participants: Fifty-six patients with mild, moderate, or severe dry eye treated by ophthalmologists in the Eye Care Services department of Henry Ford Health Care System.Testing. Patients completed interactive software utility assessment questionnaires by the time trade-off (TTO) method. Utility scores were scaled such that a score of 1.0 = perfect health and 0 = death. Dry eye severity was independently classified using clinical parameters and physician/patient assessments. Global health status, visual functioning, and ocular symptoms were assessed by the Short Form-36 Health Survey, 25-Item National Eye Institute Visual Function Questionnaire (NEI VFQ-25), and Ocular Surface Disease Index survey instruments.Main Outcome Measures: Utility scores for a range of dry eye severity states. These utilities were compared with utilities reported for other disease states. Correlations with the general and vision-related health status measures were conducted.Results: Fifty-six patients completed the utility assessments with acceptable reliability. Mean utilities for moderate (0.78) and severe dry eye (0.72) by TTO were similar to historical reports for moderate (0.75) and more severe (class III/IV) angina (0.71), respectively. Utility scores correlated with the NEI VFQ-25 composite score (p 0.32; P = 0.037) and with components of other health measures.Conclusions: Utilities for the more severe forms of dry eye are in the range of conditions like class III/IV angina (0.71) that are widely recognized as lowering health utilities. Our results underscore how significantly dry eye impacts patients compared with other medical conditions. (C) 2003 by the American Academy of Ophthalmology.