Aryloxy phosphoramidate triesters as pro-tides.
Aryloxy phosphoramidate triesters as pro-tides.
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DOI：
10.2174/1389557043403936
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发表时间：
2004-05
期刊：
影响因子：
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通讯作者：
D. Cahard;C. Mcguigan*;J. Balzarini
中科院分区：
文献类型：
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作者：
D. Cahard;C. Mcguigan*;J. Balzarini
我们在此描述了芳氧基氨基磷酸酯三酯作为有效的前肽基序的开发，用于细胞内递送带电生物活性抗病毒单磷酸核苷。该综述涵盖了此类芳基氨基磷酸酯的发现、其作用机制和构效关系。强调了该策略在一系列抗病毒核苷中的应用。
We herein describe the development of aryloxy phosphoramidate triesters as an effective pro-tide motif for the intracellular delivery of charged bio-active antiviral nucleoside monophosphates. The review covers the discovery of such aryl phosphoramidates, their mechanism of action and structure-activity relationships. The application of this strategy to a range of antiviral nucleosides is highlighted.