Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes
Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes
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DOI：
10.1523/jneurosci.2750-07.2007
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发表时间：
2007-09-05
影响因子：
5.3
通讯作者：
Marin, Oscar
中科院分区：
文献类型：
--
作者：
Flames, Nuria;Pla, Ramon;Marin, Oscar
哺乳动物的端脑被认为是所有生物结构中最复杂的。它由大量功能和形态不同的神经元组成，这些神经元协调控制着认知和行为的大多数方面。例如，苍白质下不仅产生了多种神经元类型，形成了基底神经节和部分杏仁核和隔膜，而且也是皮层中间神经元惊人多样性的起源。尽管我们对大多数这些神经元群体的分子、形态和生理特性有详细的了解，但它们产生的机制仍然知之甚少。在这里，我们全面分析了几种转录因子在发育中的小鼠苍白质下脑室区的表达模式，以生成该区域存在的不同祖结构域的详细分子图谱。我们的研究表明，小鼠皮层下的心室区包含至少18个结构域，这些结构域是由几种转录因子的组合表达所独特定义的。此外，体内微移植实验的结果证实，解剖学上确定的小鼠皮层下区域，如内侧神经节隆起，可以细分为功能不同的区域。
The mammalian telencephalon is considered the most complex of all biological structures. It comprises a large number of functionally and morphologically distinct types of neurons that coordinately control most aspects of cognition and behavior. The subpallium, for example, not only gives rise to multiple neuronal types that form the basal ganglia and parts of the amygdala and septum but also is the origin of an astonishing diversity of cortical interneurons. Despite our detailed knowledge on the molecular, morphological, and physiological properties of most of these neuronal populations, the mechanisms underlying their generation are still poorly understood. Here, we comprehensively analyzed the expression patterns of several transcription factors in the ventricular zone of the developing subpallium in the mouse to generate a detailed molecular map of the different progenitor domains present in this region. Our study demonstrates that the ventricular zone of the mouse subpallium contains at least 18 domains that are uniquely defined by the combinatorial expression of several transcription factors. Furthermore, the results of microtransplantation experiments in vivo corroborate that anatomically defined regions of the mouse subpallium, such as the medial ganglionic eminence, can be subdivided into functionally distinct domains.