The nucleotide sequence of the 5' region of rat 18S rDNA and adjoining spacer.
The nucleotide sequence of the 5' region of rat 18S rDNA and adjoining spacer.
复制标题
大鼠 18S rDNA 5 区域和相邻间隔区的核苷酸序列。
DOI：
10.1016/s0006-291x(82)80179-4
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发表时间：
1982
影响因子：
3.1
通讯作者：
Rothblum,LI
中科院分区：
文献类型：
--
作者：
Cassidy,BG;Subrahmanyan,CS;Rothblum,LI
测定了大鼠18S rDNA的前62个核苷酸以及相邻外转录间隔区的85个核苷酸的序列。大鼠与其他物种序列的同源性表明，18S rDNA的5‘末端是保守的，相邻的外部转录间隔区是发散的。建立了一个描述18S rRNA 5‘端和3’端与相邻转录间隔区之间可能相互作用的二级结构模型。这一模型提出了一种可能的结构来处理前-18S rRNA，尽管外部和内部转录间隔区的序列存在差异，但该结构显然是保守的。
The first sixty-two nucleotides of rat 18S rDNA, as well as eighty-five nucleotides of the adjacent external transcribed spacer have been sequenced. The homologies between the rat sequence and those of other species demonstrate the conservation of the 5′ terminus of 18S rDNA and the divergence of the adjacent external transcribed spacers. A secondary structure model depicting the possible interactions between the 5′ and 3′ termini of 18S rRNA and the adjacent transcribed spacers was constructed for rat andXenopuspreribosomal RNA. This model suggests a possible configuration for the processing of pre-18S rRNA which is apparently conserved despite the divergence of the sequences of the external and internal transcribed spacers.