CD36 Gene Promoter Polymorphisms Are Associated With Low Density Lipoprotein-Cholesterol in Normal Twins and After a Low-Calorie Diet in Obese Subjects
CD36 Gene Promoter Polymorphisms Are Associated With Low Density Lipoprotein-Cholesterol in Normal Twins and After a Low-Calorie Diet in Obese Subjects
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DOI：
10.1375/twin.11.6.621
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发表时间：
2008-12-01
影响因子：
0.9
通讯作者：
O'Dell, Sandra D.
中科院分区：
文献类型：
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作者：
Goyenechea, Estibaliz;Collins, Laura J.;O'Dell, Sandra D.
CD36脂肪酸转运基因的常见多态性与脂质代谢和心血管疾病有关。研究了正常受试者和肥胖受试者在8周低热量饮食和6个月体重维持期中CD36启动子单核苷酸多态性基因型与人体测量和血脂的关系。2728名英国正常女性双胞胎（平均体重指数24.8±4.4 kg/m）；年龄47.3 +/- 12.5岁)和183名肥胖的西班牙男性和女性（平均体重指数30.6 +/- 3.0 kg/m）；年龄为35.0 +/- 5.0岁的人群，基因分型为CD36 -22674 T/C （rs2151916）启动子单核苷酸多态性。在Twins UK全队列中，c等位基因与较低的低密度脂蛋白-胆固醇相关（p = 0.02, N = 2396）。在基线时肥胖的西班牙受试者中没有发现关联，但在低热量饮食结束6个月后，c等位基因与总- (p = 0.03)和低密度脂蛋白-胆固醇（p = 0.01）和较高的高密度脂蛋白-胆固醇（p = 0.01）相关。c等位基因携带者的饱和脂肪酸摄入量在基线时较低，但差异不显著（p = 0.11）。然而，在低热量饮食结束6个月后，脂质谱元素与饱和脂肪酸摄入量相关：总胆固醇r = 0.21, p = 0.060；低密度脂蛋白-胆固醇：r = 0.25, p = 0.043；高密度脂蛋白-胆固醇：r = - 0.26, p = .007。因此，CD36启动子SNP等位基因-22674C与正常女性双胞胎中较低的血清低密度脂蛋白-胆固醇以及肥胖受试者在减肥和维持体重期间改善的脂质谱有关。
Common polymorphisms of the CD36 fatty acid transporter gene have been associated with lipid metabolism and cardiovascular disease. Association of a CD36 promoter single nucleotide polymorphism genotype with anthropometry and serum lipids was investigated in normal subjects, and in obese subjects during an 8-week low calorie diet and 6-month weight-maintenance period. 2728 normal female Twins UK subjects (mean body mass index 24.8 +/- 4.4 kg/m(2); age 47.3 +/- 12.5 y) and 183 obese male and female Spanish subjects (mean body mass index 30.6 +/- 3.0 kg/m(2); age 35.0 +/- 5.0 y) were genotyped for the CD36 -22674 T/C (rs2151916) promoter single nucleotide polymorphism. In the Twins UK full cohort, the C-allele was associated with lower low density lipoprotein-cholesterol (p = .02, N = 2396). No associations were found in the obese Spanish subjects at baseline, but 6 months after the end of the low-calorie diet, the C-allele was associated with lower total- (p = .03) and low density lipoprotein-cholesterol (p = .01) and higher high density lipoprotein-cholesterol (p = .01). Intake of saturated fatty acids was lower in carriers of the C-allele at baseline, but not significantly so (p = .11). However, 6 months after the end of the low-calorie diet, elements of the lipid profile were correlated with saturated fatty acid intake: total cholesterol r = .21, p = .060; low density lipoprotein-cholesterol: r = .25, p = .043; high density lipoprotein-cholesterol: r = -.26, p = .007. CD36 promoter SNP allele -22674C is therefore associated with lower serum low-density lipoprotein-cholesterol in normal female twins and with improved lipid profile during weight loss and maintenance in obese subjects.