Virtual footprint and PRODORIC:: an integrative framework for regulon prediction in prokaryotes
Virtual footprint and PRODORIC:: an integrative framework for regulon prediction in prokaryotes
复制标题
DOI：
10.1093/bioinformatics/bti635
复制
发表时间：
2005-11-15
期刊：
影响因子：
5.8
通讯作者：
Jahn, D
中科院分区：
文献类型：
--
作者：
Münch, R;Hiller, K;Jahn, D
建立了一个新的在线框架，用于准确和综合地预测原核生物中的转录因子结合位点（TFBS）。该系统由三个相互连接的模块组成：（1）PRODORIC数据库作为一个全面的数据源和广泛收集的TFBS与相应的位置权重矩阵。(2)模式匹配工具Virtual Footprint，用于预测基于基因组的调节子和分析单个启动子区域。(3)交互式基因组浏览器GBPro用于可视化TFBS搜索结果及其基因组背景，并链接到PRODORIC中的基因和调节子特定信息。该服务的目的是为研究人员提供分子微生物学，感染和系统生物学领域的免费和易于使用的互连工具集合。
A new online framework for the accurate and integrative prediction of transcription factor binding sites (TFBSs) in prokaryotes was developed. The system consists of three interconnected modules: (1) The PRODORIC database as a comprehensive data source and extensive collection of TFBSs with corresponding position weight matrices. (2) The pattern matching tool Virtual Footprint for the prediction of genome based regulons and for the analysis of individual promoter regions. (3) The interactive genome browser GBPro for the visualization of TFBS search results in their genomic context and links to gene and regulator-specific information in PRODORIC. The aim of this service is to provide researchers a free and easy to use collection of interconnected tools in the field of molecular microbiology, infection and systems biology.