Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium.
Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium.
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DOI：
10.1371/journal.pone.0266985
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
Jouhet, Vianney
中科院分区：
文献类型：
--
作者：
Moal, Bertrand;Orieux, Arthur;Ferte, Thomas;Neuraz, Antoine;Brat, Gabriel A.;Avillach, Paul;Bonzel, Clara-Lea;Cai, Tianxi;Cho, Kelly;Cossin, Sebastien;Griffier, Romain;Hanauer, David A.;Haverkamp, Christian;Ho, Yuk-Lam;Hong, Chuan;Hutch, Meghan R.;Klann, Jeffrey G.;Le, Trang T.;Loh, Ne Hooi Will;Luo, Yuan;Makoudjou, Adeline;Morris, Michele;Mowery, Danielle L.;Olson, Karen L.;Patel, Lav P.;Samayamuthu, Malarkodi J.;Vidorreta, Fernando J. Sanz;Schriver, Emily R.;Schubert, Petra;Verdy, Guillaume;Visweswaran, Shyam;Wang, Xuan;Weber, Griffin M.;Xia, Zongqi;Yuan, William;Zhang, Harrison G.;Zoller, Daniela;Kohane, Isaac S.;Boyer, Alexandre;Jouhet, Vianney
在18至49岁的年轻人中，对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染后的急性呼吸窘迫综合征(ARDS)的调查有限。我们评估了青年人群感染SARS-CoV-2后ARDS的危险因素和结果。一项回顾性队列研究于2020年1月1日至2021年2月28日使用患者级别的电子健康记录(EHR)在241家美国医院和43家欧洲医院进行，这些医院参与了EHR(4CE)对新冠肺炎的临床特征描述联盟。为了确定与ARDS相关的危险因素，我们通过联合分析比较了患有和不患有ARDS的年轻患者。我们进一步比较了年轻和老年ARDS患者的结果。在75,377名SARS-CoV-2阳性住院患者中，1001名青壮年出现ARDS(占年轻住院成人的7.8%)。他们90天的死亡率为16.2%，他们的感染并发症发生率与患有ARDS的老年人相似。消化性溃疡疾病、瘫痪、肥胖、充血性心力衰竭、瓣膜疾病、糖尿病、慢性肺部疾病和肝脏疾病与ARDS的风险相关。我们描述了肥胖(53%)、高血压(38%-尽管与ARDS没有明显关联)和糖尿病(32%)的高患病率。通过一种创新的方法，收集了一项关于感染SARS-CoV-2后发展为ARDS的年轻人的大型国际队列研究。它表明了这一人群的不良结局和相关的风险因素。
In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population. A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS. Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%- although not significantly associated with ARDS), and diabetes (32%). Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor.
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影响因子：
7.4
作者：
Kohane IS;Aronow BJ;Avillach P;Beaulieu-Jones BK;Bellazzi R;Bradford RL;Brat GA;Cannataro M;Cimino JJ;García-Barrio N;Gehlenborg N;Ghassemi M;Gutiérrez-Sacristán A;Hanauer DA;Holmes JH;Hong C;Klann JG;Loh NHW;Luo Y;Mandl KD;Daniar M;Moore JH;Murphy SN;Neuraz A;Ngiam KY;Omenn GS;Palmer N;Patel LP;Pedrera-Jiménez M;Sliz P;South AM;Tan ALM;Taylor DM;Taylor BW;Torti C;Vallejos AK;Wagholikar KB;Consortium For Clinical Characterization Of COVID-19 By EHR (4CE);Weber GM;Cai T
通讯作者：
Cai T
影响因子：
13.8
作者：
Bourgeois FT;Gutiérrez-Sacristán A;Keller MS;Liu M;Hong C;Bonzel CL;Tan ALM;Aronow BJ;Boeker M;Booth J;Cruz Rojo J;Devkota B;García Barrio N;Gehlenborg N;Geva A;Hanauer DA;Hutch MR;Issitt RW;Klann JG;Luo Y;Mandl KD;Mao C;Moal B;Moshal KL;Murphy SN;Neuraz A;Ngiam KY;Omenn GS;Patel LP;Jiménez MP;Sebire NJ;Balazote PS;Serret-Larmande A;South AM;Spiridou A;Taylor DM;Tippmann P;Visweswaran S;Weber GM;Kohane IS;Cai T;Avillach P;Consortium for Clinical Characterization of COVID-19 by EHR (4CE)
通讯作者：
Consortium for Clinical Characterization of COVID-19 by EHR (4CE)
影响因子：
15.2
作者：
Brat, Gabriel A.;Weber, Griffin M.;Kohane, Isaac S.
通讯作者：
Kohane, Isaac S.
DOI：
10.1007/s42399-020-00476-w
发表时间：
2020-01-01
期刊：
SN comprehensive clinical medicine
影响因子：
--
作者：
Patel, Urvish;Malik, Preeti;Sacks, Henry
通讯作者：
Sacks, Henry
影响因子：
3
作者：
Elixhauser, A;Steiner, C;Coffey, RN
通讯作者：
Coffey, RN