Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory
Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory
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DOI：
10.1038/nrn2913
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发表时间：
2010-10-01
影响因子：
34.7
通讯作者：
Groc, Laurent
中科院分区：
文献类型：
--
作者：
Krugers, Harmen J.;Hoogenraad, Casper C.;Groc, Laurent
应激事件记忆的获得和巩固受到糖皮质激素的调节，糖皮质激素是一种皮质类固醇激素，在暴露于应激事件后从肾上腺释放高水平。这些作用通过盐皮质激素受体（MR）和糖皮质激素受体（GR）的激活而发生。糖皮质激素对突触传递、突触可塑性、学习和记忆的影响的分子机制最近开始被确定。糖皮质激素调节AMPA（α-氨基-3-羟基-5-甲基-4-异恶唑丙酸酯）受体的运输，这是至关重要的参与突触传递和可塑性-快速和持久。应激激素可能通过调节AMPA受体功能，促进行为相关信息的巩固。
The acquisition and consolidation of memories of stressful events is modulated by glucocorticoids, a type of corticosteroid hormone that is released in high levels from the adrenal glands after exposure to a stressful event. These effects occur through activation of mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs). The molecular mechanisms that underlie the effects of glucocorticoids on synaptic transmission, synaptic plasticity, learning and memory have recently begun to be identified. Glucocorticoids regulate AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate) receptor trafficking which is crucially involved in synaptic transmission and plasticity-both rapidly and persistently. Stress hormones may, through modulation of AMPA receptor function, promote the consolidation of behaviourally relevant information.