Measuring Biexponential Transverse Relaxation of the ASL Signal at 9.4 T to Estimate Arterial Oxygen Saturation and the Time of Exchange of Labeled Blood Water into Cortical Brain Tissue
Measuring Biexponential Transverse Relaxation of the ASL Signal at 9.4 T to Estimate Arterial Oxygen Saturation and the Time of Exchange of Labeled Blood Water into Cortical Brain Tissue
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测量 9.4 T 下 ASL 信号的双指数横向弛豫以估计动脉氧饱和度和标记的血液交换到皮质脑组织的时间
DOI：
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发表时间：
2013
影响因子：
6.3
通讯作者：
D. Thomas
中科院分区：
文献类型：
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作者：
J. Wells;B. Siow;M. Lythgoe;D. Thomas
在9.4T磁场下，测量了四种不同时间的动脉自旋标记（ASL）信号在大鼠大脑皮层的横向衰减。观察到双指数T2衰减，这似乎源自与血管内（IV）和血管外（EV）隔室中的标记水相关的不同T2值。使用双室双指数模型评估IV和EV室对ASL信号的相对贡献，而不假设血管中标记血液的T2值。这种新的方法被应用于估计交换时间的血液水到EV组织空间和血氧饱和度的血管动脉侧的血液。标记的血液水的平均交换时间估计为370 ± 40 ms。血管系统动脉侧的氧饱和度显著低于100%（~85%），这可能对定量功能磁共振成像研究有影响，其中动脉氧饱和度通常假设为100%。
The transverse decay of the arterial spin labeling (ASL) signal was measured at four inflow times in the rat brain cortex at 9.4 T. Biexponential T2 decay was observed that appears to derive from different T2 values associated with labeled water in the intravasculature (IV) and extravascular (EV) compartments. A two compartment biexponential model was used to assess the relative contribution of the IV and EV compartments to the ASL signal, without assuming a value for T2 of labeled blood water in the vessels. This novel methodology was applied to estimate the exchange time of blood water into EV tissue space and the oxygen saturation of blood on the arterial side of the vasculature. The mean exchange time of labeled blood water was estimated to be 370 ± 40 ms. The oxygen saturation of the arterial side of the vasculature was significantly less than 100% (~85%), which may have implications for quantitative functional magnetic resonance imaging studies where the arterial oxygen saturation is frequently assumed to be 100%.
DOI：
10.1073/pnas.89.12.5675
发表时间：
1992-06-15
影响因子：
11.1
作者：
KWONG, KK;BELLIVEAU, JW;ROSEN, BR
通讯作者：
ROSEN, BR