Iron-sulfur cluster biosynthesis in bacteria: Mechanisms of cluster assembly and transfer
Iron-sulfur cluster biosynthesis in bacteria: Mechanisms of cluster assembly and transfer
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DOI：
10.1016/j.abb.2007.12.014
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发表时间：
2008-06-15
影响因子：
3.9
通讯作者：
Ollagnier-de-Choudens, Sandrine
中科院分区：
文献类型：
--
作者：
Fontecave, Marc;Ollagnier-de-Choudens, Sandrine
铁硫[Fe-S]簇是普遍存在的古代假体基团，是维持基本生命过程所必需的。细胞内[Fe-S]簇的形成不是自发发生的，而是需要复杂的生物合成机制。已经发现了不同类型的[Fe-S]簇组装系统。它们的共同点是需要半胱氨酸脱硫酶和[Fe-S]支架蛋白的参与。本综述的目的是讨论生物体中[Fe-S]簇组装的分子机制的各个方面：（i）硫供体酶的机制，即半胱氨酸脱硫酶； (ii) 簇在支架蛋白上预组装的机制和 (iii) [Fe-S] 簇从支架转移到靶蛋白的机制。 (c) 2007 Elsevier Inc. 保留所有权利。
Iron-sulfur [Fe-S] clusters are ubiquitous ancient prosthetic groups that are required to sustain fundamental life processes. Formation of intracellular [Fe-S] clusters does not occur spontaneously but requires a complex biosynthetic machinery. Different types of [Fe-S] cluster assembly systems have been discovered. All of them have in common the requirement of a cysteine desulfurase and the participation of [Fe-S] scaffold proteins. The purpose of this review is to discuss various aspects of the molecular mechanisms of [Fe-S] cluster assembly in living organisms: (i) mechanism of sulfur donor enzymes, namely the cysteine desulfurases; (ii) mechanism by which clusters are preassembled on scaffold proteins and (iii) mechanism of [Fe-S] cluster transfer from scaffold to target proteins. (c) 2007 Elsevier Inc. All rights reserved.