Functional MRI of cortical activations induced by transcranial magnetic stimulation (TMS)
Functional MRI of cortical activations induced by transcranial magnetic stimulation (TMS)
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DOI：
10.1097/00001756-200111160-00034
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发表时间：
2001-11-16
期刊：
影响因子：
1.7
通讯作者：
Frahm, J
中科院分区：
文献类型：
--
作者：
Baudewig, J;Siebner, HR;Frahm, J
采用2.0T回波平面成像技术，利用血氧水平依赖（BOLD）MRI研究了重复经颅磁刺激（rTMS）对人脑活动和相关血流动力学的影响。除了双侧激活听觉皮层的听觉rTMS放电（23突发，1秒的持续时间，10赫兹，10-20秒的刺激间隔），BOLD反应被限制到皮质表示的实际手指运动进行自愿或诱发阈上rTMS的运动皮层。无论是阈下rTMS的运动皮层，也不阈上rTMS的外侧运动前皮层诱导可检测的BOLD反应。这些发现表明，神经元去极化诱导rTMS调制尖峰输出的大脑区域，但不会自动改变脑血流和氧合。BOLD MRI激活的观察可能反映了真实的运动的传入皮质内处理。(C)2001年利平科特威廉姆斯&威尔金斯。
The effects of repetitive transcranial magnetic stimulation (rTMS) on human brain activity and associated hemodynamics were investigated by blood-oxygenation-level-dependent (BOLD) MRI using echo-planar imaging at 2.0 T. Apart from bilateral activation of the auditory cortex by the audible rTMS discharges (23 bursts, 1 s duration, 10 Hz, 10-20 s interstimulus intervals), BOLD responses were restricted to cortical representations of actual finger movements performed either voluntarily or evoked by suprathreshold rTMS of the motor cortex. Neither subthreshold rTMS of the motor cortex nor suprathreshold rTMS of the lateral premotor cortex induced a detectable BOLD response. These findings suggest that neuronal depolarization as induced by rTMS modulates the spiking output of a brain area but does not automatically alter cerebral blood flow and oxygenation. The observation of BOLD MRI activations probably reflects the afferent intracortical processing of real movements. (C) 2001 Lippincott Williams & Wilkins.