The diversity and abundance of gut microbiota are associated with the pain sensation threshold in the Japanese population
The diversity and abundance of gut microbiota are associated with the pain sensation threshold in the Japanese population
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DOI：
10.1016/j.nbd.2022.105839
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发表时间：
2022-08-23
影响因子：
6.1
通讯作者：
Nakaji, Shigeyuki
中科院分区：
文献类型：
--
作者：
Takeuchi, Yuki;Mizukami, Hiroki;Nakaji, Shigeyuki
小纤维神经病（SFN）是糖尿病性多发性神经病（DPN）的初始病理。血清脂多糖结合蛋白水平与足痛阈呈正相关，提示肠道内丰富的革兰氏阴性杆菌（脂多糖的来源）可能参与DPN的发展。此外，肠道和口腔微生物群的丰度被认为与糖尿病的发病机制有关。然而，SFN和微生物群之间的联系尚未得到澄清。2018年岩城健康促进项目共招募了1056人。根据表皮内电刺激（PINT）的疼痛阈值评价疼痛感觉。具有PINT评分的患者
Small fibre neuropathy (SFN) is an initial pathology of diabetic polyneuropathy (DPN). Serum lipopolysaccharide binding protein levels are positively correlated with the pain threshold in the foot, suggesting that the abundance of gut Gram-negative bacilli, which are a source of lipopolysaccharides, may be involved in the development of DPN. Furthermore, the abundance of the gut and oral microbiota is assumed to be involved in the pathogenesis of diabetes. Nevertheless, the association between SFN and the microbiota has not been clarified. A total of 1056 individuals were recruited in the 2018 Iwaki Health Promotion Project. Pain sensation was evaluated based on the pain threshold from intraepidermal electrical stimulation (PINT). Patients with PINT scores