Experimental investigation of the flow of bile in patient specific cystic duct models.
Experimental investigation of the flow of bile in patient specific cystic duct models.
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DOI：
10.1115/1.4001043
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
M. Al-Atabi;S. Chin;X. Luo
中科院分区：
文献类型：
--
作者：
M. Al-Atabi;S. Chin;X. Luo
在解剖标本的基础上，制备了3个人体囊管的三维放大透明模型。在复制生理状态的条件下，测量囊管模型的压降并可视化这些管道内的流动结构。流动可视化研究证实胆汁在胆囊管内呈层流流动，压降系数（Cp）值随着雷诺数（Re）的增加而降低。三种被试模型的雷诺数与压降系数曲线表现出相似的特性。结果表明，与直管相比，囊管的压降增大，流动结构复杂。胆囊管的高阻力可能表明胆囊在将胆汁排出到胆囊管时必须施加很大的力。对于胆囊病变患者，甚至是健康人，胆囊会随着年龄的增长而变硬，并可能失去其顺应性或灵活性。高阻力的胆囊管与硬化的胆囊相结合，可能导致胆囊内胆汁淤积时间延长，这被认为会促进胆结石的形成。
Three-dimensional scaled-up transparent models of three human cystic ducts were prepared on the basis of anatomical specimens. The measurement of pressure drop across the cystic duct models and visualization of the flow structures within these ducts were performed at conditions replicating the physiological state. The flow visualization study confirmed the laminar nature of the flow of bile inside the cystic duct and values of pressure drop coefficient (Cp) decreased as the Reynolds number (Re) increased. The three tested models showed comparable behavior for the curve of Reynolds number versus the pressure drop coefficient. The results show that the tested cystic ducts have both increased pressure drop and complicated flow structures when compared with straight conduits. High resistance in a cystic duct may indicate that the gallbladder has to exert large force in expelling bile to the cystic duct. For patients with diseased gallbladder, and even in healthy persons, gallbladder is known to stiffen with age and it may lose its compliance or flexibility. A high resistance cystic duct coupled with a stiffened gallbladder may result in prolonged stasis of bile in the gallbladder, which is assumed to encourage the formation of gallstones.