TP53 Arg72Pro Polymorphism and Skin Cancer Risk: A Meta-Analysis
TP53 Arg72Pro Polymorphism and Skin Cancer Risk: A Meta-Analysis
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DOI：
10.1038/jid.2010.270
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发表时间：
2011-01-01
影响因子：
6.5
通讯作者：
Yu, Long
中科院分区：
文献类型：
--
作者：
Jiang, De-Ke;Wang, Wen-Zhang;Yu, Long
TP53 基因在保护细胞免受紫外线照射造成的 DNA 损伤方面发挥着重要作用，该基因的序列变异可能会改变皮肤癌的易感性。为了检查 TP53 Arg72Pro 多态性与皮肤癌风险之间的关联，我们对涉及 6,362 名受试者的 15 项病例对照研究进行了荟萃分析。研究的质量是根据预定的量表进行评估的。使用随机效应模型评估具有 95% 置信区间 (CI) 的粗比值比 (OR) 的关联性。总体而言，在任何遗传模型中均未观察到 TP53 基因型与皮肤癌风险之间存在关联的证据（Arg/Arg 与 Pro/Pro：OR = 1.05，95% CI：0.71-1.55；Arg/Pro 与 Pro/Pro：OR = 0.92，95% CI：0.68-1.24；Arg/Arg + Arg/Pro 与 Pro/Pro：OR = 0.97，95% CI：0.70-1.35；Arg/Arg 与 Arg/Pro + Pro/Pro：OR 1.15，95% CI：0.91-1.46）。根据研究的种族和质量评分进行分层分析也发现在任何亚组中都没有显着关联。此外，没有观察到这种多态性对皮肤癌亚型，如黑色素瘤、鳞状细胞癌和基底细胞癌的影响。总之，这项荟萃分析表明 TP53 Arg72Pro 多态性可能与皮肤癌易感性关系不大。
The TP53 gene has an important role in the protection of cells from DNA damage due to UV exposure, and sequence variation in the gene may alter skin cancer susceptibility. To examine the association between the TP53 Arg72Pro polymorphism and skin cancer risk, we undertook a meta-analysis of 15 case-control studies involving 6,362 subjects. The quality of the studies was assessed according to a predefined scale. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were assessed for association using a random-effects model. Overall, no evidence of association was observed between TP53 genotypes and the risk of skin cancer in any genetic model (Arg/Arg vs. Pro/Pro: OR = 1.05, 95% CI: 0.71-1.55; Arg/Pro vs. Pro/Pro: OR = 0.92, 95% CI: 0.68-1.24; Arg/Arg + Arg/Pro vs. Pro/Pro: OR = 0.97, 95% CI: 0.70-1.35; Arg/Arg vs. Arg/Pro + Pro/Pro: OR 1.15, 95% CI: 0.91-1.46). Stratified analyses according to ethnicity and quality score of the studies also detected no significant association in any subgroup. Furthermore, no effect of this polymorphism on subtype of skin cancer, such as melanoma, squamous cell carcinoma, and basal cell carcinoma, was observed. In conclusion, this meta-analysis suggests that the TP53 Arg72Pro polymorphism may have little involvement in skin cancer susceptibility.