Increased expression of GAB1 promotes inflammation and fibrosis in systemic sclerosis
Increased expression of GAB1 promotes inflammation and fibrosis in systemic sclerosis
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GAB1表达增加促进系统性硬化症中的炎症和纤维化
DOI：
10.1111/exd.14033
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发表时间：
2019-11-01
影响因子：
3.6
通讯作者：
Wu, Wenyu
中科院分区：
文献类型：
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作者：
Shi, Xiangguang;Liu, Qingmei;Wu, Wenyu
系统性硬化症是一种以持续性炎症和纤维化为主要特征的自身免疫性疾病。受体酪氨酸激酶（receptor tyrosine kinase，RTK）信号通路在SSc的发病过程中起着重要作用，而Grb 2相关结合蛋白（GAB）在激活RTK信号通路中起着关键作用。先前的一项研究发现，在博莱霉素（BLM）诱导的纤维化肺中，GAB1水平升高，但GAB1在SSc中的作用仍不清楚。我们的目的是研究GAB 1是否失调及其在SSc中的潜在作用。我们发现，与健康供体相比，SSc患者外周血单个核细胞（PBMC）中GAB1的表达高1.6倍，CD4 + T细胞中高2.5倍，皮肤中高2倍（P
Systemic sclerosis (SSc) is an autoimmune disease mainly characterized by persistent inflammation and fibrosis. The receptor tyrosine kinase (RTK) signal pathway plays an important role in the process of SSc, and Grb2-associated binding protein (GAB) is crucial in activating RTK signalling. A previous study found elevated levels of GAB1 in bleomycin (BLM)-induced fibrotic lungs, but the effects of GAB1 in SSc remain unclear. Our aim was to investigate whether GAB1 was dysregulated and its potential role in SSc. Compared with healthy donors, we found GAB1 expression was 1.6-fold higher in peripheral blood mononuclear cells (PBMC), 2.5-fold higher in CD4 + T cells, and 2-fold higher in skin from of SSc patients (P