PRIMARY AND SECONDARY BILATERAL SYNCHRONY IN EPILEPSY - DIFFERENTIATION BY ESTIMATION OF INTERHEMISPHERIC SMALL TIME DIFFERENCES DURING SHORT SPIKE-WAVE ACTIVITY
PRIMARY AND SECONDARY BILATERAL SYNCHRONY IN EPILEPSY - DIFFERENTIATION BY ESTIMATION OF INTERHEMISPHERIC SMALL TIME DIFFERENCES DURING SHORT SPIKE-WAVE ACTIVITY
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DOI：
10.1016/0013-4694(92)90022-a
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发表时间：
1992-08-01
期刊：
影响因子：
--
通讯作者：
OHTAHARA, S
中科院分区：
文献类型：
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作者：
KOBAYASHI, K;OHTSUKA, Y;OHTAHARA, S
通过相干和相位分析估计EEG中棘波爆发期间的半球间小时间差（TD）有助于区分癫痫的原发性双侧同步（PBS）和继发性双侧同步（SBS）。由于先前通过快速傅立叶变换的方法需要长脉冲串才能进行可靠的分析，因此新开发了使用二维自回归模型的方法，即使在1.2秒的脉冲串中也能估计TD，并将其应用于19名具有明显双侧同步棘波脉冲串的癫痫患者。在10名临床诊断为特发性、隐源性或症状性全身性癫痫的患者中，估计的最大TD为5.8 msec或更小，并且在主导半球中不一致，表明PBS，7例有临床症状的部分性癫痫和2例有症状的全身性癫痫患者的最大TD为9.3- 41.5msec，与导联一致，提示SBS。5例TD在阵发的中端有消失的趋势，3例TD在阵发的中端无消失的趋势，提示SBS有2种不同的病理生理机制。
Estimation of interhemispheric small time differences (TDs) during spike-wave bursts in the EEG by coherence and phase analysis is useful for differentiation between primary bilateral synchrony (PBS) and secondary bilateral synchrony (SBS) in epilepsy. Because the previous method via Fast Fourier Transform needed long bursts for reliable analysis, a method using a 2-dimensional autoregressive model was newly developed to enable estimation of TDs even in 1.2 sec bursts, and applied to 19 epileptic patients with apparently bilaterally synchronous spike-wave bursts.At the onsets of bursts, estimated maximal TDs were 5.8 msec or less and inconsistent in leading hemispheres in 10 patients with a clinical diagnosis of idiopathic, cryptogenic or symptomatic generalized epilepsy indicating PBS, while the maximal TDs were 9.3-41.5 msec and consistent in leading in 7 patients with clinically symptomatic partial epilepsy and also in two with idiopathic and symptomatic generalized epilepsy suggesting SBS.Among 8 patients with bursts which suggested SBS and long enough for evaluation of intra-burst TD variation, TDs tended to disappear in the middle to end parts of the bursts in 5 cases, but not in the other 3, suggesting 2 different pathophysiological mechanisms in SBS.