Dopamine overflow is increased in olfactory bulbectomized rats: an in vivo microdialysis study.
Dopamine overflow is increased in olfactory bulbectomized rats: an in vivo microdialysis study.
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嗅球切除大鼠的多巴胺溢出增加：一项体内微透析研究。
DOI：
10.1016/j.physbeh.2004.01.003
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Edwards,GaylenL
中科院分区：
文献类型：
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作者：
Masini,CherV;Holmes,PhilipV;Freeman,KimberlyG;Maki,AlexandraC;Edwards,GaylenL
大鼠嗅球切除术（OBX）产生的行为，生理和神经化学变化类似于人类抑郁症的症状。因此，该程序可用作情感障碍的啮齿动物模型。OBX的许多行为效应类似于精神激动。腹侧纹状体多巴胺（DA）系统的失调在这种现象中的可能作用进行了研究。DA，去甲肾上腺素（NE），高香草酸，二羟基苯乙酸，和5-羟基吲哚乙酸的基础水平进行了检查，在纹状体的OBX和假手术的控制，使用在体内微透析。OBX大鼠表现出显着较高的基础DA水平（192%）和较低的NE水平（12%）比假手术对照组。OBX大鼠对新奇刺激和足电击应激的自发活动升高。纹状体中更高的DA水平的发现可以解释这种“激动样”行为，这是OBX模型中常见的现象。
Olfactory bulbectomy (OBX) in rats produces behavioral, physiological, and neurochemical changes that resemble symptoms of depression in humans. The procedure thus serves as a rodent model of affective disorder. Many of the behavioral effects of OBX resemble psychomotor agitation. The possible role of dysregulation of ventral striatal dopamine (DA) systems in this phenomenon was investigated. Basal levels of DA, norepinephrine (NE), homovanillic acid, dihydroxyphenylacetic acid, and 5-hydroxyindoleacetic acid were examined in the striatum of OBX and sham-operated controls using in vivo microdialysis. OBX rats exhibited significantly higher basal DA levels (192%) and lower NE levels (12%) than sham-operated controls. Locomotor activity in response to novelty and footshock stress was elevated in OBX rats. The finding of higher DA levels in striatum may explain this “agitation-like” behavior, a commonly observed phenomenon in the OBX model.