Infiltration of diametrically polarized macrophages predicts overall survival of patients with gastric cancer after surgical resection
Infiltration of diametrically polarized macrophages predicts overall survival of patients with gastric cancer after surgical resection
复制标题
直径极化巨噬细胞的浸润可预测手术切除后胃癌患者的总生存期
DOI：
10.1007/s10120-014-0422-7
复制
发表时间：
2015-10-01
期刊：
影响因子：
7.4
通讯作者：
Sun, Yihong
中科院分区：
文献类型：
--
作者：
Zhang, Heng;Wang, Xuefei;Sun, Yihong
BackgroundTumor-associated macrophages (TAMs), the most predominant tumor-infiltrating immune cells, are emerging prognostic factors and therapeutic targets for personalized therapy against malignant neoplasms. We aimed to evaluate the prognostic significance of diametrically polarized TAMs in gastric cancer and generate a predictive nomogram to refine a risk stratification system.MethodsWe evaluated polarized functional status of infiltrated TAMs by immunohistochemical staining of CD68, CD11c, and CD206 in 180 consecutive gastric cancer patients from Zhongshan Hospital, Shanghai, China. Prognostic values were assessed in these patients. We created a predictive nomogram by integrating polarized TAMs with the TNM staging system for overall survival of gastric cancer patients.ResultsCD68+TAMs display polarized programs comprising CD11c+proinflammatory macrophages (M1) and CD206+immunosuppressive macrophages (M2) that configure versatile infiltration files in gastric cancer. CD11c+TAMs negatively correlated with lymph node metastasis (p= 0.012), whereas CD206+TAMs correlated with the Lauren classification (p= 0.031). No prognostic difference was observed for overall survival for CD68 density (highvslow,p= 0.1031), whereas high versus low CD11c density (p< 0.0001) and lowvshigh CD206 density (p= 0.0105) indicate better overall survival. Multivariate Cox regression analysis identified CD11c and CD206 as independent prognostic factors (p< 0.001 andp= 0.030, respectively), which could be integrated with the TNM staging system to generate a predictive nomogram for patient outcomes.ConclusionInfiltration of polarized TAMs, a novel identified independent prognostic factor, could be combined with the TNM stage to refine a risk stratification system and better stratify patients with different prognosis. Tipping TAMs to an antitumoral phenotype might be a promising therapeutic target for postoperative treatment.
