PREVENTIVE EFFECT OF A LACTOBACILLUS-CASEI PREPARATION ON THE RECURRENCE OF SUPERFICIAL BLADDER-CANCER IN A DOUBLE-BLIND TRIAL
PREVENTIVE EFFECT OF A LACTOBACILLUS-CASEI PREPARATION ON THE RECURRENCE OF SUPERFICIAL BLADDER-CANCER IN A DOUBLE-BLIND TRIAL
复制标题
DOI：
10.1159/000475138
复制
发表时间：
1995-01-01
期刊：
影响因子：
23.4
通讯作者：
NAITO, S
中科院分区：
文献类型：
--
作者：
ASO, Y;AKAZA, H;NAITO, S
对138例经尿道膀胱浅表性移行细胞癌切除术后的患者进行了双盲试验，以评估口服干酪乳杆菌制剂（BLP）对复发的预防作用。将患者分为以下3个亚组：(A)原发多发肿瘤；(B)单个肿瘤复发，(C)多发肿瘤复发。在每一组中，患者被随机分配接受BLP或安慰剂。在a、B亚组中，BLP的预防效果优于安慰剂，而在c亚组中，BLP的预防效果无显著性差异。Cox多因素分析显示，BLP的预防效果明显优于安慰剂（p = 0.01）。3名接受BLP治疗的患者和3名安慰剂治疗的患者发生了轻微和可容忍的不良反应。口服BLP对预防浅表性膀胱癌复发安全有效。
A double-blind trial was conducted in 138 patients with superficial transitional cell carcinoma of the bladder following transurethral resection to evaluate the prophylaxis of recurrence by an oral Lactobacillus casei preparation (BLP). Patients were stratified into the following 3 subgroups: (A) with primary multiple tumors; (B) with recurrent single tumors, and (C) with recurrent multiple tumors. In each group, patients were randomly allocated to receive BLP or placebo. BLP showed a better prophylactic effect in subgroups A and B than placebo, whereas no significant difference was observed in subgroup C. Cox multivariate analysis showed that the outcome with BLP was significantly better than with placebo (p = 0.01). Slight and tolerable adverse reactions occurred in 3 patients receiving BLP and in 3 of the placebo-treated patients. Oral administration of BLP was thus safe and effective for preventing recurrence of superficial bladder cancer.