HYPOFRONTALITY IN PANIC DISORDER AND MAJOR DEPRESSIVE DISORDER ASSESSED BY MULTI-CHANNEL NEAR-INFRARED SPECTROSCOPY
HYPOFRONTALITY IN PANIC DISORDER AND MAJOR DEPRESSIVE DISORDER ASSESSED BY MULTI-CHANNEL NEAR-INFRARED SPECTROSCOPY
复制标题
DOI：
10.1002/da.20463
复制
发表时间：
2008-01-01
影响因子：
7.4
通讯作者：
Mimura, Masaru
中科院分区：
文献类型：
--
作者：
Ohta, Haruhisa;Yamagata, Bun;Mimura, Masaru
背景：惊恐障碍是一种常见的使人衰弱的精神疾病，然而，这种障碍的神经生物学尚未完全了解。焦虑相关神经回路过度活跃的前额叶抑制控制缺陷与惊恐障碍的病理生理核心有关。本研究的目的是探讨是否惊恐障碍揭示额叶功能障碍，同时执行的文字流畅性测试，通过使用多通道近红外光谱，并比较惊恐障碍与抑郁症的结果。方法：21例惊恐障碍患者、17例抑郁症患者和24例健康对照者参加了本研究。结果如下：与健康对照组相比，惊恐障碍和重度抑郁症患者在双侧额叶区域的单词流畅性测试中显示出类似的氧合血红蛋白增加减弱。惊恐障碍和重度抑郁症的前额功能减退在左内侧下额叶最为突出。结论：本研究阐明了惊恐障碍的前额叶功能减退是明显的，即使是中性刺激的情绪负荷很小。抑郁和焦虑25：1053-1059，2008. (C)2008 Wiley-Liss，Inc.
Background: Panic disorder is a common and debilitating psychiatric disease; yet, the neurobiology of this disorder is not fully understood. Deficits in the prefrontal inhibitory control over hyperactivity of the anxiety-related neural circuit are implicated in the pathophysiological core of panic disorder. The aims of this study were to investigate whether panic disorder reveals frontal lobe dysfunction while performing the word fluency test by using multi-channel near-infrared spectroscopy and to compare the findings in panic disorder with those in major depressive disorder. Methods: Twenty-one patients with panic disorder 17 patients with major depressive disorder and 24 healthy control subjects participated in the study. Results: Both patients with panic disorder and with major depressive disorder showed similarly attenuated increases in oxyhemoglobin during the word fluency test in the bilateral frontal regions, when compared to healthy control participants. Hypofrontality in panic disorder and major depressive disorder was most prominent in the left medial inferior frontal lobe. Conclusions: This study clarified that hypofrontality in panic disorder is evident even with neutral stimuli of little emotional load. Depression and Anxiety 25:1053-1059, 2008. (C) 2008 Wiley-Liss, Inc.