Non-genomic mechanisms of progesterone action in the brain.
Non-genomic mechanisms of progesterone action in the brain.
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DOI：
10.3389/fnins.2013.00159
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发表时间：
2013-09-19
影响因子：
4.3
通讯作者：
Ng S
中科院分区：
文献类型：
--
作者：
Singh M;Su C;Ng S
黄体酮是一种性腺类固醇激素，其生理作用远远超出了生殖功能的严格范围。事实上，黄体酮可以对多种组织产生重要影响，包括骨骼、心脏和大脑。从机制上讲，黄体酮被认为是通过黄体酮受体（PR）（核类固醇激素超家族的成员）发挥其作用，因此通过靶基因启动子区域内的特定黄体酮反应元件（PRE）发挥作用，以调节此类基因的转录。这通常被描述为黄体酮作用的“基因组”机制。然而，正如孕酮具有多种组织靶标一样，孕酮引起其作用的机制也同样多种多样。例如，黄体酮可以激活替代受体，例如膜相关 PR（与经典 PR 不同），从而引发多种信号通路的激活，进而影响细胞功能。在这里，我们回顾了黄体酮可以招募以引发其作用的各种非核（即非基因组）信号传导机制，我们的讨论主要集中在黄体酮影响大脑细胞活力的信号传导机制上。
Progesterone is a gonadal steroid hormone whose physiological effects extend well beyond the strict confines of reproductive function. In fact, progesterone can have important effects on a variety of tissues, including the bone, the heart and the brain. Mechanistically, progesterone has been thought to exert its effects through the progesterone receptor (PR), a member of the nuclear steroid hormone superfamily, and as such, acts through specific progesterone response elements (PRE) within the promoter region of target genes to regulate transcription of such genes. This has been often described as the “genomic” mechanism of progesterone action. However, just as progesterone has a diverse range of tissue targets, the mechanisms through which progesterone elicits its effects are equally diverse. For example, progesterone can activate alternative receptors, such as membrane-associated PRs (distinct from the classical PR), to elicit the activation of several signaling pathways that in turn, can influence cell function. Here, we review various non-nuclear (i.e., non-genomic) signaling mechanisms that progesterone can recruit to elicit its effects, focusing our discussion primarily on those signaling mechanisms by which progesterone influences cell viability in the brain.
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影响因子：
5.3
作者：
Hoffman, GE;Moore, N;Murphy, AZ
通讯作者：
Murphy, AZ
影响因子：
16
作者：
Boonyaratanakornkit, V;Scott, MP;Edwards, DP
通讯作者：
Edwards, DP
影响因子：
5.3
作者：
He, J;Evans, CO;Stein, DG
通讯作者：
Stein, DG
DOI：
10.1002/neu.20327
发表时间：
2006-11-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
Bell-Horner, Cathy L.;Dohi, Akiko;Singh, Meharvan
通讯作者：
Singh, Meharvan
影响因子：
5.8
作者：
BIKLE, DD;HALLORAN, BP;PORTALE, AA
通讯作者：
PORTALE, AA