Rhodium-catalyzed asymmetric 1,6-addition of aryltitanates to enynones giving axially chiral allenes
Rhodium-catalyzed asymmetric 1,6-addition of aryltitanates to enynones giving axially chiral allenes
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DOI：
10.1021/ol036309f
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发表时间：
2004-01-22
期刊：
影响因子：
5.2
通讯作者：
Inoue, K
中科院分区：
文献类型：
--
作者：
Hayashi, T;Tokunaga, N;Inoue, K
[图片]芳基钛酸盐试剂ArTi(OPr-i)(4)Li在三甲基氯硅烷和铑-(R)-二氢磷的存在下，以1,6的方式加入到3-炔基-2-烯-1- 1中，得到了高收率的轴向手性烯基烯基硅烯醇醚，ee高达93%。
[GRAPHICS]The addition of aryltitanate reagents ArTi(OPr-i)(4)Li to 3-alkynyl-2-en-1-ones in the presence of chlorotrimethylsilane and a rhodium-(R)-segphos as a catalyst proceeded in a 1,6-fashion to give a high yield of axially chiral allenylalkenyl silyl enol ethers with up to 93% ee.