1ST-PASS CARDIAC PERFUSION - EVALUATION WITH ULTRAFAST MR IMAGING
1ST-PASS CARDIAC PERFUSION - EVALUATION WITH ULTRAFAST MR IMAGING
复制标题
DOI：
10.1148/radiology.174.3.2305058
复制
发表时间：
1990-03-01
期刊：
影响因子：
19.7
通讯作者：
EDELMAN, RR
中科院分区：
文献类型：
--
作者：
ATKINSON, DJ;BURSTEIN, D;EDELMAN, RR
作者研究了心脏灌注钆二乙烯三胺五乙酸（DTPA）与超快成像技术，产生强烈的T1加权图像。该方法包括180 ° C的温度。反转脉冲，随后是重复时间非常短（< 4 msec）的梯度回波采集。每幅图像都是在心动周期的一小部分中采集的。该方法被应用在一个孤立的灌注大鼠心脏模型（采集时间= 116毫秒），并在人类受试者没有已知的心脏疾病（采集时间= 125毫秒）。快速、高分辨率的图像（128 × 128）128矩阵）通过组合顺序获得的小矩阵来创建。在灌流大鼠心脏模型中，团注Gd-DTPA后，非灌流心肌和灌流正常心肌之间的对比明显。在灌注大鼠心脏模型和人类受试者中观察造影剂的首过洗入和洗出阶段。 结果证明了心脏首过灌注研究的临床可行性。研究可以在具有标准硬件的常规全身成像系统上进行。
The authors studied cardiac perfusion by administering gadolinium diethylenetriaminepentaacetic acid (DTPA) in conjunction with an ultrafast imaging technique that produces strongly T1-weighted images. The method consisted of a 180.degree. inversion pulse, followed by a gradient-echo acquisition with a very short repetition time (< 4 msec). Each image was acquired throughout a small fraction of the cardiac cycle. The method was applied in an isolated perfused rat heart model (acquisition time = 116 msec) and in human subjects without known cardiac disease (acquisition time = 125 msec). Fast, high-resolution images (128 .times. 128 matrix) were created by combining sequentially acquired small matrixes. After bolus administration of Gd-DTPA in the perfused rat heart model, contrast was pronounced between the nonperfused myocardium and perfused normal myocardium. First-pass wash-in and washout phases of the contrast material were observed in the perfused rat hear model and in human subjects. Results demonstrated the clinical feasibility of first-pass perfusion studies of the heart. The studies can be performed on a conventional whole-body imaging system with standard hardware.