Engineered liposomes targeting the gut-CNS Axis for comprehensive therapy of spinal cord injury
Engineered liposomes targeting the gut-CNS Axis for comprehensive therapy of spinal cord injury
复制标题
靶向肠道-中枢神经系统轴的工程脂质体用于脊髓损伤的综合治疗
DOI：
10.1016/j.jconrel.2021.01.032
复制
发表时间：
2021-01-30
影响因子：
10.8
通讯作者：
Li, Chong
中科院分区：
文献类型：
--
作者：
Wang, Xue;Wu, Jin;Li, Chong
脊髓损伤通常伴有肠道并发症，目前缺乏有效的治疗方法。潜在的治疗靶点包括星形胶质细胞及其肠神经系统对应物肠胶质细胞（EGCs）。基于两种细胞类型共享的生物标志物和相似的功能，我们设计了一种口服靶向给药系统，该系统采用硫代硒稳定神经肽apamin作为靶向片段，脂质体表面用非共价交联壳聚糖乳酸层保护。该系统有效地穿过口服吸收屏障，靶向体循环后的局部EGCs和星形胶质细胞，使脊髓损伤的综合治疗成为可能。鉴于肠道器官轴参与越来越多的疾病，我们的研究可能会揭示口服给药途径作为多重干预和靶向治疗的旁路途径的新方面。
Effective curative therapies for spinal cord injury (SCI), which is often accompanied by intestinal complications, are lacking. Potential therapeutic targets include astrocytes and their enteric nervous system counterpart, enteric glial cells (EGCs). Based on shared biomarkers and similar functions of both cell types, we designed an orally administered targeted delivery system in which the neuropeptide apamin, stabilized by sulfur replacement with selenium, was adopted as a targeting moiety, and the liposome surface was protected with a non-covalent cross-linked chitosan oligosaccharide lactate layer. The system effectively permeated through oral absorption barriers, targeted local EGCs and astrocytes after systemic circulation, allowing for comprehensive SCI therapy. Given the involvement of the gut-organ axis in a growing number of diseases, our research may shed light on new aspects of the oral administration route as a bypass for multiple interventions and targeted therapy.