Increased Amygdala Responses to Sad But Not Fearful Faces in Major Depression: Relation to Mood State and Pharmacological Treatment
Increased Amygdala Responses to Sad But Not Fearful Faces in Major Depression: Relation to Mood State and Pharmacological Treatment
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DOI：
10.1176/appi.ajp.2012.11121774
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发表时间：
2012-08-01
影响因子：
17.7
通讯作者：
Anderson, Ian M.
中科院分区：
文献类型：
--
作者：
Arnone, Danilo;McKie, Shane;Anderson, Ian M.
目的：在功能性磁共振成像（fMRI）中观察到的杏仁核对负面情绪的反应增加已被提出作为负面情绪处理偏见的生物标志物，这些偏见是抑郁症状和抑郁复发的脆弱性的基础，这些症状和抑郁复发通过抗抑郁药物治疗而正常化。本研究的目的是确定抑郁症患者杏仁核对面部情绪的异常反应是否与特定的情绪或抗抑郁治疗反应的变化有关，以及它们是否作为一种稳定的特征存在于缓解期的无药物治疗患者中。方法：62例无药物治疗的单相抑郁症患者（38人目前抑郁，24人在缓解）和54名健康对照受试者进行了间接的面部情绪处理任务在功能磁共振成像。32名目前患有抑郁症的患者接受了为期8周的抗抑郁药西酞普兰治疗。治疗的依从性进行了评估，通过测量西酞普兰血浆concentration.Results：目前抑郁症患者增加了双边杏仁核的反应，具体到悲伤的面孔相对于健康的对照组和非药物治疗的患者在稳定的缓解。西酞普兰治疗取消了异常杏仁核反应悲伤的面孔，目前抑郁症患者，但没有改变反应恐惧faces.Conclusions：异常杏仁核激活悲伤的面部情绪是特定的抑郁状态，是一个潜在的生物标志物在抑郁发作期间的负面情感偏见。
Objective: Increased amygdala response to negative emotions seen in functional MRI (fMRI) has been proposed as a biomarker for negative emotion processing bias underlying depressive symptoms and vulnerability to depressive relapse that are normalized by antidepressant drug treatment. The purpose of this study was to determine whether abnormal amygdala responses to face emotions in depression are related to specific emotions or change in response to antidepressant treatment and whether they are present as a stable trait in medication-free patients in remission.Method: Sixty-two medication-free unipolar depressed patients (38 were currently depressed, and 24 were in remission) and 54 healthy comparison subjects underwent an indirect face-emotion processing task during fMRI. Thirty-two currently depressed patients were treated with the antidepressant citalopram for 8 weeks. Adherence to treatment was evaluated by measuring citalopram plasma concentrations.Results: Patients with current depression had increased bilateral amygdala responses specific to sad faces relative to healthy comparison subjects and non-medicated patients in stable remission. Treatment with citalopram abolished the abnormal amygdala responses to sad faces in currently depressed patients but did not alter responses to fearful faces.Conclusions: Aberrant amygdala activation in response to sad facial emotions is specific to the depressed state and is a potential biomarker for a negative affective bias during a depressive episode.