Screening for early-onset invasive group B Streptococcal disease in neonates in an Irish hospital (2001-2014): a retrospective audit
Screening for early-onset invasive group B Streptococcal disease in neonates in an Irish hospital (2001-2014): a retrospective audit
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DOI：
10.1080/23744235.2017.1285045
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发表时间：
2017-01-01
影响因子：
5.8
通讯作者：
Drew, Richard J.
中科院分区：
文献类型：
--
作者：
Nielsen, Maryke;Sheikh, Naveed;Drew, Richard J.
B 族链球菌 (GBS) 是早发性新生儿败血症和脑膜炎的最常见原因。对于临床上没有怀疑感染的婴儿，由于母体危险因素而有患早发性侵袭性疾病的风险，需要进行血培养以检测菌血症。在我们的机构中，对有脓毒症临床症状的婴儿进行腰椎穿刺，但不对筛查时状况良好的婴儿进行腰椎穿刺。 2001年至2014年间，共有112,361名体重>500克的活产婴儿，其中13,959名（12.4%）婴儿在出生后第一天或第二天进行了血培养，其中1971名（14.1%）婴儿在出生后头两天进行了腰椎穿刺。确定了 53 例早发 GBS 疾病病例。只有三名患有侵袭性 GBS 疾病的患者在测试时没有临床怀疑患有脓毒症。因此，检测一名在检测时状况良好的婴儿中检测出 GBS 菌血症的血培养数量为 3996 例。
Group B Streptococcus (GBS) is the most common cause of early-onset neonatal sepsis and meningitis. In babies with no clinical suspicion of infection, who are at risk of early-onset invasive disease based on maternal risk factors, blood cultures are taken to detect bacteraemia. In our institution, lumbar punctures are performed in infants with clinical signs of sepsis but not in infants who are well at the time of screening. Between 2001 and 2014, there were 112,361 live births weighing >500g, of whom 13,959 (12.4%) infants had a blood culture taken on the first or second day of life, and 1971 (14.1%) of these infants had lumbar punctures on these first two days of life. Fifty-three cases of early-onset GBS disease were identified. Only three patients with invasive GBS disease had no clinical suspicion for sepsis at the time of testing. Thus, the number of blood cultures taken to detect one case of GBS bacteraemia in an infant who is well at the time of testing was 3996.